Brand Name: Phenergan
Other brand Name(s):
Generic Name(s): Promethazine hydrochloride
Generic Ingredient(s):

Patient Information Sheet from the US Food and Drug Administration

Promethazine (marketed as Phenergan)

This is a summary of the most important information about promethazine. For details, talk to your healthcare professional.

FDA approved labeling for promethazine contains a serious warning about the risk of serious breathing problems when promethazine is used by children.

What Is Promethazine?

Promethazine is an antihistamine which can be taken by mouth as a tablet or syrup, rectally as a suppository, or by injection. It can be used for:

• “hay fever,” or, a stuffy runny nose from allergy
• watery, itchy eyes due to inhaled allergies and foods
• mild allergic skin reactions with itching and swelling
• allergic reactions to blood or plasma
• dermographism, a form of hives known as “skin writing”
• serious allergic reactions along with epinephrine and other treatments
• sedation before or after surgery, or during childbirth
• prevention and control of nausea and vomiting after surgery
• along with meperidine (demerol) or other pain medicines
• sedation, relief of anxiety, and production of light sleep from which the patient can be easily aroused
• treatment and prevention of motion sickness

Who Should Not Use Promethazine?

Promethazine should not be given to:

• children under two years of age
• patients who are unconscious
• patients who are allergic to promethazine, any of the ingredients in promethazine, or to other phenothiazines
• patients with lung symptoms including asthma
• children who are vomiting unless the vomiting is prolonged and there is a known cause

What Are The Risks?
The following are the major potential risks and side effects of promethazine therapy. However, this list is not complete.

• Severe drowsiness and reduced mental alertness. Promethazine may cause drowsiness which may impair your ability to ride a bike, drive a car, or operate machinery. This may be worsened if taken with alcohol or other drugs that also cause central nervous system (CNS) slowing such as sedatives, pain medicines, tranquilizers or certain drugs for depression.
• Serious breathing problems. Promethazine should not be used in patients with poor lung function such as chronic obstructive lung disease or breathing problems while sleeping (sleep apnea).
• Increased risk of seizures. Promethazine should be used with caution in patients with seizures or who are on other medicines which may also increase the risk of seizures.
• Bone-marrow problems and blood cell production. Promethazine should not be used in patients with bone-marrow problems or used with other drugs that affect the bone marrow’s production of blood cells.
• Neuroleptic malignant syndrome. This potentially deadly syndrome includes symptoms such as fever, muscle rigidity, mental changes, changes in pulse or blood pressure, fast heartbeat, increased sweating or irregular heart rhythm.
• The most common side effects are drowsiness, changes in blood pressure, skin reactions, blood cell changes and breathing problems. Increased excitability or abnormal movements may occur after one dose of promethazine. If they do, consult your doctor about using another medicine.

What Should I Tell My Healthcare Professional?

Before you start taking promethazine, tell your healthcare professional if you:

• have narrow-angle glaucoma
• have an enlarged prostate
• have a stomach ulcer
• have an intestinal blockage
• have a bladder blockage
• have heart problems
• have liver problems
• have breathing or lung problems
• have sleep apnea (breathing problems when sleeping)
• have seizures
• drink alcohol
• are trying to become pregnant, are already pregnant, or are breast-feeding

Can Other Medicines Or Food Affect Promethazine?

Promethazine and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how promethazine works or promethazine may affect how your other medicines work. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Especially tell your healthcare professional if you take:

• medicines that affect your brain such as anti-anxiety medicine, sleeping pills, pain medicines, sedatives, narcotics, antidepressants or tranquilizers
• epinephrine
• a monoamine oxidase inhibitor (MAOI) which is used to treat depression or other mental disorders
• medicines called anticholinergics

Brand Name: Pyridium
Other brand Name(s):
Generic Name(s): Phenazopyridine hydrochloride
Generic Ingredient(s):

Brand Name: Adipex-P
Other brand Name(s): Ionamin
Generic Name(s): Phentermine hydrochloride
Generic Ingredient(s):

Brand Name: Pepcid
Other brand Name(s): Pepcid AC, Pepcid RPD
Generic Name(s): Famotidine
Generic Ingredient(s):

Brand Name: Prilosec
Other brand Name(s):
Generic Name(s): Omeprazole
Generic Ingredient(s):

Brand Name: Norflex
Other brand Name(s):
Generic Name(s): Orphenadrine
Generic Ingredient(s):

Brand Name: Levitra
Other brand Name(s):
Generic Name(s): Vardenafil
Generic Ingredient(s):

Patient Information Sheet from the US Food and Drug Administration

Vardenafil hydrochloride (marketed as Levitra)

This is a summary of the most important information about Levitra. For details, talk to your healthcare professional.

FDA ALERT [07/2005]: A small number of men have lost eyesight in one eye some time after taking Levitra, Viagra, or Cialis. This type of vision loss is called non-arteritic anterior ischemic optic neuropathy (NAION). NAION causes a sudden loss of eyesight because blood flow is blocked to the optic nerve.

We do not know at this time if Levitra, Viagra, or Cialis cause NAION. NAION also happens in men who do not take these medicines. People who have a higher chance for NAION include those who:

• have heart disease

• are over 50 years old

• have diabetes

• have high blood pressure

• have high cholesterol

• smoke

• have certain eye problems

FDA has approved new labels for Levitra, Viagra, and Cialis to include information on possible eyesight loss (NAION).

Stop using Levitra, Viagra, or Cialis if you have a loss in your eyesight. Get medical help right away.

This information reflects FDA’s current analysis of data available to FDA concerning this drug. FDA intends to update this sheet when additional information or analyses become available.

What is Levitra?

Levitra is a medicine taken by mouth for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. Levitra may help a man with ED get and keep an erection when he is sexually excited. Levitra must be used only under a doctor's care.
Levitra does not:

• cure ED

• increase a man’s sexual desire

• protect a man or his partner from sexually transmitted diseases, including HIV. Speak to your healthcare professional about ways to guard against sexually transmitted diseases.

• serve as a male form of birth control

Levitra is only for men with ED. Levitra is not for women or children. Levitra must be used only under a healthcare professional’s care.

Who Should Not Take Levitra?

Do not take Levitra if you:

• take any medicines called “nitrates”

• use recreational drugs called "poppers" like amyl nitrate and butyl nitrate

• have been told by your healthcare professional not to have sexual activity because you have health problems

What are The Risks?

The following are the major possible risks and side effects of Levitra therapy. This list is not complete.

Levitra can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines such as nitrates and alpha-blockers, and recreational drugs that contain nitrates called "poppers". A sudden drop in your blood pressure could cause you to become dizzy, faint, or have a heart attack or stroke.

Tell all your healthcare professionals that you take Levitra. If you need emergency medical care for a heart problem, it will be important for your healthcare professionals to know when you last took Levitra.

Levitra may uncommonly cause:

• an erection that won’t go away (priapism)

• vision changes, such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green

Some common side effects with Levitra include:

• headache

• flushing

• stuffy or runny nose

• indigestion

• upset stomach

• dizziness

What Should I Tell My Healthcare Professional?

Tell your healthcare professional if you:

• have or had heart problems

• have low blood pressure or have high blood pressure that is not controlled

• have had a stroke

• or any family members have a rare heart condition known as prolongation of the QT interval (long QT syndrome)

• have liver problems

• have kidney problems and require dialysis

• have ever had severe vision loss

• have retinitis pigmentosa, a rare genetic (runs in families) eye disease

• have stomach ulcers

• have a bleeding problem

• have a deformed penis shape or Peyronie’s disease

• have had an erection that lasted more than 4 hours

• take any medicines called “alpha blockers” (alpha blockers are sometimes prescribed for prostate problems or high blood pressure)

• have blood cell problems, such as sickle cell anemia, multiple myeloma, or leukemia

Can Other Medicines or Food Affect Levitra?

Levitra and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Brand Name: Percocet
Other brand Name(s): Roxicet, Tylox
Generic Name(s): Endocet
Generic Ingredient(s): Acetaminophen, Oxycodone hydrochloride

Brand Name: Methadose
Other brand Name(s): Dolophine
Generic Name(s): Methadone
Generic Ingredient(s):

Brand Name: Subutex
Other brand Name(s):
Generic Name(s):
Generic Ingredient(s): Buprenorphine