March 1, 2009 - 6:58pm
My Pm doc gave me a script for the morphine IR 30's in case i can't locate the oxy 30's. Have some of you tried the morphine during the oxy shortage. How do they compare as far as pain reduction and side effects? Will i experience any WD's changing over? Would sure appreciate any comments from you all.
take care
March 2, 2009 - 7:33pm
#2
Morphine compared to oxy, in
Morphine compared to oxy, in my experience will make you little more ichy than normal. Morphine is also a bit more dopey feeling. It should work well for you. I've gone from oxy to morphine once n my pain controlled just fine. As far as the Oxy IR, I get 30mg oxy ir and they can be hard to locate, but they ARE out there, just like a &*&? shot trying to find it. Good Luck! LoL
March 5, 2009 - 8:50am
#3
same position
My doc also switched me over from oxyIR 30's to MSIR 30's but he gave me double the dose because he wanted to make sure i didnt go into withdrawals and had enough to take care of my pain. Just got them yesterday, but let me know how it worked for you please.
March 5, 2009 - 9:37am
#4
Tea Parties
This is about how this entire, thoughtless, mess impacts We, The People. As a disabled senior, I am scared to death about the cutbacks we are experiencing due to the fact they we are not a good investment. In the last three months, I have had my Medicaid medical transportation cancelled, two important meds. no longer covered by my Part D. and I can not access the outpatient physical therapy I need to get out of a wheelchair.
Susan
KY
March 5, 2009 - 9:38pm
#5
I have found that to
I have found that to allow for bioavailability you would need 40-45 mg IR Morphine sulphate to equate with 30MG Oxycodones.
Best of Luck
All comments are the users opinion, and is not to be taken for professional mediacl advice, all medical advice should be sought from a medical health professional. I am merely a student.
March 8, 2009 - 5:06pm
#6
LexyLady
LexyLady i feel so bad for you. I know that will not help, but have you looked into other transportation means? I know where i live the hospital will pick up patients and take them to the hospital. Have you looked into non-profts for transportation? If you can find a non-profit org that offers help with your disease/condition to assist in pt. Are there privately owned transportation folks? If so (my husbands best friend owns one) call them an ask about assisting. My husband friends company are all EMTs and they own/drive ambulances. If i lived near you i would offer help. I only wish you the best of luck,htmom
* Maybe if any fellow pharmers out there own a transportation company in your area are willing to help or know any non-profits that could help you
March 8, 2009 - 6:48pm
#7
Comparability
In terms of potency, oral morphine is about half the potency as oxycodone. This basically means that 5mg of oxycodone is about equal to 10mg of morphine in terms of pain relief. Morphine releases more histamine in the body, causing itchiness, moreso than oxycodone. Morphine is a strong agonist of the Mu opiate receptor, while oxycodone is a moderate agonist. What this means is that morphine should relieve pain greater than oxycodone. This sounds confusing, because oxycodone is more potent than morphine. However, this is due to the first pass effect of the liver. When a dose of morphine is taken orally, the liver breaks down about 70 percent of the dose right off the bat into inactive compounds. With oxycodone, it is only 30 percent.
March 8, 2009 - 8:15pm
#8
Exactly
Bingo, you got it.
All comments are the users opinion, are not to be taken for professional mediacl advice, all medical advice should be sought from a medical health professional. I am merely a student.
March 9, 2009 - 12:18pm
#9
Hey htmom!!!!!!!
The hospital is the only place I can get to. When I moved into town from the country, I got an apartment for the elderly/disabled across the street from the hospital. I have a four wheel scooter which gets me there safely.
My pain doc is about four mile away. I have contacted numerous non-profits and our local AARP with no luck. They say, and it is true that I SHOULD be getting free transportation through Medicaid. My services were terminated because they said I no longer meet the criteria. Not true and a I am contesting the termination. Medicaid has also terminated my visiting home health nurse and everyone is having fits over that decision. Thankfully, I still have an aid that comes twice a week to help me take a real shower and runs errands for me. That contract will up for review in nine months.
The going rate with the cab co. is $15.00 for the first five miles. A trip to the pain doc would be $45.00. I get charged $15.00 when he stops at the pharmacy and runs through the drive through. The doc faxes my scripts and everything is ready when we go through but it is still considered a seperate trip, in spite of the fact that we pass it on the way home. I do take the city bus. The route from here to there takes an hour and it is a bumpy trip.
Lexy
March 9, 2009 - 2:04pm
#10
Comparibility Switched
I was switched from oxyir 55mg a day/ 5mg (3) 3times a day and 2 at night to hydromorphone (4mg tab= 12mg a day. I sort of understood what you said but was wondering how instant release oxycodone works in the body in comparision to hydromorphone. I was told when pm dr. gets back from vacation adjustments can be made as it appeared to me from the onset that I was prescribed way less then should be also told take 1-2 a.m. and 1tab p.m. The whole thing does not make sense to me anyway so I am trying to figure out what the difference is in the body as you wrote above but regarding morphine and if possibly you would know if their is a chemical reason of why I would be prescribed 1-2 a.m. and 1 tab p.m. and nothing during the day. I have researched on other websites however I do not really understand the language need it all in laymens terms. Thanks for any responses and replies and I do not mean to be annoying with this I just want to be informed as possible and I am SCAAAAAAAAARed. Thanks Jamie P.S. I know as far as extended release when I went from Meth to Oxyer (over a year ago) my pm dr had to lower my dosage and informed me I would feel withdrawls but that he would get me back up their so I am wondering if he is doing the same with the oxy ir vs the dilaudid. Even if he was in town right now to ask him would be to step on toes as pm dr would feel I was doing his job. I however like to be educated on what is going on. BTW these are my breakthrough meds. Thanks again
March 9, 2009 - 2:07pm
#11
SO Sorry
If I lived in your area I would be more then happy to help however I am in Florida. Will see if I can get any info for KY and possibly some options for you. I pray you receive the help you need. Take care, Jamie
March 10, 2009 - 12:25am
#12
jamie L answer from RPh.
Basically, all opiates work the same way: activating opiate receptors in the central nervous system. These receptors are very complex, and when activated, they suppress pain transmission in the body. In short, they remove the sensation of pain even though the underlying injury still exists. The difference between opiates is two way: potency and receptor activity. Potency means how much of the drug it takes to relieve pain. Receptor activity refers to how strong the opiate binds to the receptor. Codeine and hydrocodone are weak to moderate potencies, oxycodone is moderate, and morphine, hydromorphone, oxymorphone and fentanyl are strong. Oxycodone gets broken down in the liver to inactive compounds, as well as oxymorphone. Hydromorphone mostly stays intact in the body, and is much stronger than oxycodone in terms of receptor activity. What this means is that hydromorphone relieves pain at lower doses compared to oxycodone. (1-2 mg of hydromorphone is about equivalent to 5-6mg of oxycodone). I honestly don't know why the doctor gave those directions, because all oral opiates (excluding methadone) have pain relieving activity of around 4-6 hours. So I would say that 4 mg of hydromorphone every 8 hours would be equivalent to taking 12mg of oxycodone for the same time frame. Hope I helped!
March 11, 2009 - 4:46pm
#13
Worried for nothing switching meds!
My regular pharmacy (Savon) had plenty of the oxy 30's to fill my script. So no trying the morphine sulfate at this time, but you never know about next month! Hopefully the shortage is getting better.
Thanks everyone for your comments. Take care.
March 14, 2009 - 7:19pm
#14
PainAngel, how's the change in meds working for you?
I never did switch over to the morphine 30ir's, because my pharm had the oxy 30ir's. Thank god! So how are you doing on the MSIR 30's? You mentioned he doubled the dose to avoid oxy withdrawals. What's the dose and did it work for you? You never know, I might not have the same luck next month getting the oxy's. i hope you are doing fine.
Looking forword to your reply and take care.
T-rex
March 21, 2009 - 3:34pm
#15
From Oxycodone 15IR to IR Morphine Sulfate 15 x*#&s for me !
About two months ago i couldt get my oxycodone 15 mg's so my NP put me on imediate release morphine sulphate 15 mg. (MS Contin) That was on a Sat, by monday i was having full blown withdrawells, had to go back to the doc and luckily he gave me a script for some oxys with tylenol (10/325's) to get me through until i could get my 15s. I take 60 mg ms contin 2 times daily and 15 mg oxys 4 times daily normally, but going to no oxys at all was a bad thing.
I could swear I posted a response on this thread once but I don't see it now. I would be concerned about WD's from changing types of drugs. I know for a fact that hydrocodone will not stop a morphine WD. So, I would definitly worry about that happenning.