July 16, 2009 - 9:10pm
Hi every1; I have lightning metabolism and what I consider substantial opioid tolerance. I have tried fentanyl, oxycontin, morphine sulfate ER, as well as other IR opiates to manage chronic pain per my very trusted primary care physician.
Recently I was scripted hydromorphone 8mg to use on a prn basis for breakthrough episodes, but the oral tabs seem to be no better than tic tacs at reducing my discomfort. I had been using extended release oxycodone and MS but felt like they were burning through my system so fast that I became a clock watcher if you catch my drift. My career is very athletically-oriented and the duragesic transdermals seemed on the money but they wouldn't stay adhered because I'd sweat like a beast.
Am I just being impatient because I'm frustrated with the new stuff or is there some1 who can shed some personal insight n2 my quandary? Thanks in advance for your wisdom nuggets.
July 16, 2009 - 11:00pm
#2
Oh yeah...
Dilaudud is the holy grail for opioid addicts. They're not taking them p.o. of course...
As for your "fatty meal" idea, i think it's great if you can do it every day. hah. Administration with a high fat meal should enhance oxycodone's effect if anything. One Big Mac a day with your OC huh...The lengths we have to go to...
In all seriousness, there is a thread on here titled "Fentanyl." Some people here use the patch and have discussed using some type of adhesive tape wrapped around the patch to keep it in place, even when sweating...might wanna look into it.
P.S. As for sentiments on Dilaudid, I have one...I didn't enjoy the time I was overdosed on Dilaudid HP while in the hospital. No fun at all. 
Take care.
July 17, 2009 - 9:37am
#3
According to LexiComp
Drug information handbook 2009
For Oxycodone:
Food: When taken with a high-fat meal, peak concentration is 25% greater following a single OxyContin 160mg tablet as compared to two 80mg tablets.
Ray
July 17, 2009 - 2:01pm
#4
Sure, and when was the last
Sure, and when was the last time you could get a 160mg OxyContin from the pharmacy? Just saying!
July 18, 2009 - 11:07am
#5
Well, it's been a while
since they made 160mg tablets, but that was just for comparison....It is the same for any dosage, they just used that as an example
Ray
bioavailabilty is poor. Duration of action is 3 hours. Dilaudid is a poor choice for someone with a high rate of metabolism. Unless, of course, you enjoy eating them like tic-tacs.
You didn't mention MSIR by name, have you given that a go?
Good luck friend.
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