April 6, 2008 - 3:55pm
I have found M357 vicodin to be less effective than brand name drug. Anyone else?
April 6, 2008 - 6:39pm
#2
If the pound of bricks was
If the pound of bricks was made by Mallinkcrodt and the pound of feathers by any other generic company, than I would have to say that the pound of feathers weighs more. 
April 7, 2008 - 5:01am
#3
I always thought
I always thought mallinkcrodt made a good product....I actually like there 10mg lortab better than qualitest...Although I still prefer UCB or watson for hydrocodone....i think it's an aesthetic thing.....
Ray
Remember: Just do it.. EVERY PILL EVERY DAY
April 11, 2008 - 7:24am
#4
It is all psychological,
It is all psychological, though many of the manufacturers use different binders and fillers the active ingredient is the same and will typically have the same psychoactive effect regardless of maker.
April 12, 2008 - 5:35am
#5
It is psychological.....all
It is psychological.....all generics are required to have the same drug, amount, and absorbtion rate......Colors and fillers are optional....I've never taken a generic and felt that it didn't work as well as the name brand
Ray
Remember: Just do it.. EVERY PILL EVERY DAY
April 12, 2008 - 6:22am
#6
The ONLY difference in the
The ONLY difference in the pill is the name.
April 12, 2008 - 7:58pm
#7
When a med can have up to
When a med can have up to 20% difference in fillers, there is definitely room for there to be a difference in the effect it has on someone. What if one company uses 100% hydrocodone/acetaminophen in their pill, while another company uses 80% hydro/apap and 20% non-effective fillers? There would obviously be a large difference in the effect then- and this is what any one of those pills may have.
Just as some people have allergies while others do not, some of the fillers have difference effects on one's body than other fillers do. This does not mean all pills are different, just that there is a possibility of it.
I'm a social worker, not a medical professional. All comments and thoughts are simply my opinion and experience.
April 12, 2008 - 8:23pm
#8
Some companies have better
Some companies have better track records than others when it comes to sub-potent or super-potent recalls. If youve ever worked in a manufacturing enviroment there are always +/- quality standards/tolerances. There are also always lazy people that would just try to get that one last batch squeezed out with the bottom of the bin of materials instead of changing the drum. There are also things like shift changes, and breaks where products arent monitored as carefully as other times throughout the day. Its not like they test every single pill that comes out of those machines.
June 12, 2008 - 8:52pm
#9
my thoughts exactly
I just got the M357's from a new Pharmacy, and I am really surprised at how weak they are, compared to the Watson 349's, or the Vicodin 5/500's.
They have much less effect on me. I took 2 W349's after 2 M357's, and they differerence was VERY noticable.
June 12, 2008 - 9:11pm
#10
well psychological or not
well psychological or not when i was on hydros i did notice a difference in the mallinckrodt pills. sometimes i wondered if they forgot to put the hydrocodone in the pills.
June 13, 2008 - 12:04am
#11
May as well just take
May as well just take asprin...sorry had to say that
June 13, 2008 - 1:45am
#12
ive been windering that as
ive been windering that as well
I almost cant even feel them.
June 13, 2008 - 10:05am
#13
I concur
I concur DONEDOSER.
June 13, 2008 - 2:59pm
#14
It's more of a Gatrointestinal thing for me
The filler, or the time-release mechanism (for extended-release meds) can definitely be different. I am missing the last portion of my small intestine, and had trouble with generic Oxycontin (it was available then). The where and how of the time-release mechanism as to how it is absorbed was simply different than brand-name. I did much better with brand-name, or the Watson generic- which was the brand licensed by Oxycontin's maker and pretty much exactly the same.
I have noticed that once or twice I have had a script filled and the pills seemed more (or less) potent. I know these things happen, there will only be a big stink and a recall if there is a really big difference. But the fact that they DO recalls b/c drugs are sub- or super-potent shows that it does occur.
Sometimes the generic version of a drug is made by the same company, in the same lab that makes the brand name, the only difference being a color dye. If you notice a difference between these pills, that is probably psychological, though some people do react to the dyes.
June 13, 2008 - 9:41pm
#15
everyone reacts differently
everyone reacts differently to everything though, that is why some people like certain brands or a generic when others may not.
I'm a social worker, not a medical professional. All comments and thoughts are simply my opinion and experience.
July 21, 2008 - 9:46pm
#16
357
people its like putting two shots of jim beam in coke or putting it in seven up ,no matter what the mix is theres still two shots of jim beam in there.
July 21, 2008 - 10:10pm
#17
[quote=people its like
Quote:
people its like putting two shots of jim beam in coke or putting it in seven up ,no matter what the mix is theres still two shots of jim beam in there.
Hilarious.
gtrplayer
July 22, 2008 - 10:21am
#18
I also have to laugh and
I also have to laugh and possibly use that comparison in the feature, love it!
July 22, 2008 - 10:41am
#19
You're Not Alone
Solomel12, you're not alone.
October 5, 2008 - 1:25am
#20
Not all generics are the same
Hi
I was Pharmacy Tech in past years, and a couple of things come to mind about generic drugs:
ALL of the (Hospital) Pharmacies I have worked at, A-L-L of them, had one or more Generic products and/or manufacturers, that the Director of Pharmacy refused to order. Reason? Patient complaint and some double blind tests the pharmacy ran within itself on everything from antibiotics to analgesics. (for those of you saying we did something illegal, we had a hosptial doc PRESCRIBE the meds the "test subjects" took, proving that the generic in question has not the same Bioavailability, regardless what the Pharmaceutical Industry controlled FDA and DEA says)!
Anyway, here is the meat of the story: As one highly intelligent fella put it, who was an RpH, plus held a Masters Degree AND a PhD in Pharmacology, said this: "Five people can take the exact same base materials, use the same pans and oven, and each of he five can bake the same flavor of cake. As you cooks know (esp those who have ever been to a pie judging contest), ALL of those 5 pies used the same ingredients, used the same pans and used the same oven.
Also, I know from personal experience, that all generics are NOT the same, i.e. various preperations of Digoxin, various preps of some epileptic drug....and yes, some preps of PAIN PILLS. The most common compaint I have heard regards the Blue 10/500 Hydrocodone-APAP pills made by Watson to others, who are usually white.
Anyone else have pharmaceutical experience who would like to share a story? Folks, knowing that one generic does not appear to work for you when another drug containing the same base drugs (such as 10mg Hydrocodone) most certainly doe.
Lemme know what you think!
Best Blessings,
Rev David Carter, DD (PhD Candidate).....Christian Chaplain/Minister
(edited to remove email address)
August 4, 2009 - 10:51am
#21
a pharmacist's opinion
I once had a pharmacist tell me that mallinkcrodt was a "bottom of the barrel" product & would not purchase that brand. He was a watson fan I guess.
October 12, 2009 - 4:15pm
#22
M357 vicodin
Well I notice that when i take the generic brand of Vicodin I itch.. but when i take the name brand I dont itch my dr what he did is didnt tell me he was switching me to name brand when I told him my problem. and I called the next day and let him know i was not itching anymore.. and he chuckled and said good now I know to perscribe you name brand and not generic.. all people react to all meds diffrently.. remember that.
Compared to what? The M357 is only 5mg hydrocodone, 500mg acetaminophen. Perhaps you are just experiencing the tolerance your body normally develops from narcotic pain medications. Maybe 5mg was sufficient for your pain in the past, but since your body now is developing that tolerance, you may need to up your dosage to 7.5mg or even 10mg. There really isnt a difference between a generic & a brand name. The compounds and quantities are the same. Its kind of like asking which weighs more....a pound of brick or a pound of feathers?