Hi, I'm new to pharmer.org. In my wanderings around the site I noticed quite a lot of comments (mostly negative) about Mallinckrodt. I was wondering if there are consistent problems with their products? I do not work for Mallinckrodt, but in the effort to be a well informed consumer, I'd like to know if it is a company to steer clear of if given the choice.
Everyone has an opinion, but as far as meds go, they affect different people in different ways. What one person may say is lousy, another may think its the best. Dont just write them off without trying for yourself. You may be one that really likes them as apposed to other manufacturers.
--MUDEBONE--
I would agree Bonnie! I have found the MS contins that mallinkrodt make to be fine. However, I have had some endos and they were OK. But for me the watson brand just plain sucks. Just gotta try them all. What particular med are you referring to....if I may ask???
I am a cancer patient who was originally prescribed pain medication made by Roxane, considered to be a good company.
Hi ! I have been off line for a while (I tend to go through waves on the computer - sorry! But to answer/update, I am prescribed 10mg tabs of Oxycodone and my pharmacy fills my Rx with Mallinkrodt. I get the feeling it just is not working as well as it should. I was thinking of swtching pharmacies to see if another brand might be better. I spoke to my Doc because I thought maybe tolerance might be an issue.
All this pales in comparison to what happened today. My Rx is for a LOT of tabs. I have AS and am in considerable pain at times. Anyway, I'm used to the small round white scored tab with an M surrounded with a box, and a scored back with the numbers 05/52. Well in the Rx I had filled on the 23rd, I just noticed SOME of the tabs looked a little different. Still an M, but no box. Also a little broader diameter, and, well, very slightly faceted. They are a little thinner - almost wafer like, and the back has a 10 but not really scored, but rather a line or hash mark in the north south orientatiion (not sufficient to brake the tab). But the tabs look VERY similar - most people - especially those in pain or the elderly would not have seen the difference, but I really noticed.
While I know that sometimes in large RXs they will run out of one brand and supplement with another - I got a weird vibe with this. I Did Not take any of the unfamiliar tabs. I just called my pharmacist (a good one) and he was alarmed (he does not do the pill counting, the assistant does that). From my verbal description he thought it might be Methylphenidate. How does Methyphenidate get mixed into an opiate Rx!! I'm sending him the mysterious tabs ASAP as the pharmacy is quite out of the way for me and I cannot drop by that easily. But I'm rethinking the pharmacy and the method of dispensing. Does anybody out there know if medicines can be dispensed Factory Sealed to remove "human error". I think this is super important with these types of drugs.
I just called my Pain doc to give him the heads up. The pharmacy is in the same building, and a lot of his patients get their meds there. I can just imagine my doc getting a lot of calls over the weekend from patients having really weird symptoms..and of course there is no way my doc could possibly know why his patients were freaking out!!
I go out of my way to be super dilligent with my opiates. NEVER mailorder - always check the RX before I leave the pharmacy...all the squeeky clean stuff. It just goes to show that even a super A++ patient can get into trouble with these meds!
This is SCARY!!!!
Any hints on making my Rxs safer would be appreciated. You can email me directly.( I think my email is on the pharmer system, but I'm new to all this and a little mystified as to how things work)
Let me guess which drug you're talking about, since you didn't come out and say in your post. My guess would be: Methadone! I went through the same thing, only the opposite way around. My pharmacy (a big chain pharmacy, not a Mom & Pop) were dispensing Methadose by Mallinckrodt when I started on Methadone over four years ago. I too, take a large number of pills a day. I'M on 180 mg per day. I told the head pharmacist that I wouldn'y fill my scripts there unless they would order my Methadone by Roxane. They did and every month I go in and fill my script for 540 Methadone tabs.
I've heard similar stories about Walgreen's and I have one close to my house, but I wouldn't go there to fill any of my scripts. Rite Aid is in the same boat and they're right across the street from Walgreen's. ginjeff, I hope you're getting the Roxane medications you want. I would really like to hear how things are going since you posted back in April.
Director
However, you don't necessarily need to switch pharmacies if you enjoy the service you receive. Just ask them if there is a possibility that they can special order a different manufacturer [Teva comes to mind, though I've heard some complaints of anaphylaxis due to the potassium content in the binders/fillers for a small, select few] of your medication, but of course there are many manufacturers available. Often times, a pharmacy will accommodate a patient, especially if you reassure the staff that you will continue to come in so long as they order the brand that works for you. At any rate, it's worth a try and likely easier than exploring multiple pharmacies to see what they are carrying [as well as, pharmacies may change their preffered manufacturer due to warehouse changes].
[n o t h i n g : e v e r y t h i n g : : r e a l i t y]
Bonnie,Im going to try and answer a few of your questions and try to clear up any confusions.
M 0552 is not 10mg Oxycodone it is 5mg Oxycodone, this could be why they arent working as well as what you used to get.
Its weird that your pharmacist said he doesnt count the pills, Oxycodone is a CII and the pharmacist is required to be the one to handle all CII medications, usually techs can only handle CIII and below.
Some pharmacies will indeed give you sealed factory bottles of medications, Ive never asked for them but I have received them. I do think however that the Pharmacists are actually required to count them out and put them in a new bottle on the bottles Ive received it said "DO NOT DISPENSE IN THIS CONTAINER". If you ask they will probably give you sealed bottles though. Just so you know most factory bottles come in quanties of 100,500 and 1000. There are exceptions and inbetweens just not with Oxycodone tablets from any manufacturer that Im aware of.
Methyphenidate 10mg is indeed the tablets that where mixed with your
Oxycodone 5mg Tablets
Courtesy of www.mallinckrodt.com
Also, ATAXIA Teva only makes generic Oxycodone Extended Release tablets so thats not an option. And most people say Teva is a bad generic just like Mallinckrodt anyways.
Well Bonnie,there has been quite a few comments in here that Mallinckrodt has made inferior products. For myself I have only been on one narcotic that was Mallinckrodt,that being Oxycodone 30 mg IR. Although now the phamacy I still use had that brand for a few months then switched to Amide generic. I myself could feel no difference, in other words they worked for me as well as the other 2 brands the other being Ethex. But the amount of people complaining about Mallinckrodt is numerous so I would have to have questions regarding this brand.I myself will no longer accept Mallinckrodt for the 30 mg oxycodone for this reason alone. I call up or when I drop by the phamacy the 1st question is what brand name they have for that medication.
First off, most Roxane products are brand name. These would include roxicodone 5, 15 and 30mg oxycodone IR tablets. There is also roxicodone 5mg/5ml oxycodone solution. Then you have Roxicet 5/325, Roxicet 5/500 and Roxidone 4.88/325 tablets, (I might be mistaken and it might be Roxinol, i cant remember) which are equivalents to percocet, tylox and percodan. It may be that your insurance would no longer pay for the roxane version, as in most cases, it is considered a brand name drug. This is especially true with the roxicodone products as roxane (also known as xanodyne pharm.) was the original producer of 5, 15 and 30mg oxycodone IR. True, that there is also OxyIR by perdue (originally in a capsule, 5mg strength only) and Percolone, by endo/dupont phamr which was the 5mg tablet. But roxane was definitely the original producer of 15 and 30mg oxycodone IR tablets. So most pharmacies consider roxane products brand name so if your ins. doesnt cover brand rx's when a cheaper (and in some cases less effective) generic is available.
As far a mallinckrodt goes, they seem to work just as well as other generics although I do prefer watson products, and with roxicodone, I prefer the amide generic.
PDX
Kinda off subject but, Roxiprin was Roxanes' Aspirin containing combination. it is now Discontinued. It looks like Endo and Watson are the only ones still making this combo.
This is what it contained when they did make it,
4.5mg Oxycodone HCL
0.38mg Oxycodone Terephthalate
325mg Aspirin
Thats what it was roxiprin. I knew roxane made a percodan product but couldnt remember the exact name. What eaxctly are roxinol and roxidone as I sweear I have heard of those two somewhere. And you're correct roxiprin was 4.88/325 combo broken down to 4.5mg oxycodone hcl,0.38mg oyxcodone terepthalate and 325mg aspirin. I did not know roxande had discontinued it though. Percodan is not widely prescribed anymore but I find it much more effective than percocet or plain oxycodone for migraine headaches.
PDX
Absolutely!!! I chose CVS for my pain contract after which they switched to Mall. Horrible!! Less than half the relief, and twice as long to kick in. If you want it to work you have to double up, which does not go over well when the dr. expects you to be taking a certain amount. I have let mine know about the horrible quality, and that it didnt work, when before it worked great. I guess in a way it worked out though, it cinched my duragesic rx. I pick it up on monday,25mcg / hour to start and work up. I hope it works.
I too check everything very carefully. Last time the pharmacy filled HALF of my oxy script! Had I not noticed it right away, I probably would have had to try and make it till my next app on half the meds. Pharmacists really dont pay attention, they just print fill print fill print fill.
There are 3 types of oxy IR 30 mg's I take for breakthrough Roxane is not one of them, as the pharmacist told me there is no BRAND NAME for 15mg or 30 mg
I think that the Mallinckrodt hydrocodone 10/500 and 10/650 are nowhere near as effective as the Qualitest or Watson brands. Even a 7.5/500 from Watson was better than the Mallinckrodt 100/650's, which surprised me as the Watson Lorcets are very effective to my pain. The Walgreens in town here uses Watson, at least I thought they did...
Roxane does indeed make oxycodone IR (i.e. roxicodone) in 5, 15, and 30mg strengths. If your pharmacy told you otherwise, then they don't carry the product or a flat out lying. I know that the brand name OxyIR by Purdue Pharma was originally a 5mg oxycodone IR capsule. Purdue does not manufacture 15 and 30mg IR oxycodone products, just a 5mg IR capsule, and their ER oxycontin products. These as well as OxyFast solution 20mg per 1ml are the only oxycodone products produced by Purdue. And a little hint, i thinmk every pill manufactured by roxane/xanodyne has a 54 followed by more #'s but the first part of the imprint will always be 54 .........
PDX
Teva (the worst of the worst), I believe, always has a 93 on all of their 'products'. I use that term loosely. I'm on OxyContin 20mg 2x/day for a herniated disc and as soon as the generic Watson and Endo supply dried up, I will not take anything but Purdue. Teva has some filler in their pills that just does not agree with me. Same with Dava/Impax, the other "authorized" OC generic. I still have yet to find out why Purdue dropped Watson as the official authorized generic. Same pill, different imprint, and you'd think it would have saved Purdue money and also given them control of the generic OC's as well?
Re Mallinckrodt, I agree completely. I have yet to take any of their generic pain pills that even made a dent in pain relief. Watson is a far superior company and used to pretty much have a monopoly on generic hydrocodone/oxycodone products, but a few years ago it seems like every big chain (Walgreen's, CVS, Rite Aid, Eckerd) switched to the Mallies. Endo makes a very good generic oxycodone/APAP (probably because it's the same as a brand Percocet with a different stamp on the pill), in my opinion. I don't know much about Roxane and next to nothing about Amide or Ethex, but those I know who take the Mallie morphine and oxycodone IR products have the same complaints as I do about their generic hydrocodone/oxycodone products.
-qh
I am not saying that Roxane never made the 15mg or 30mg Oxycodones for I know they did They no longer make those. It is Mallincrodt, Amide and Ethex. Roxanne maybe merged with one of these companies but they no longer are made with the Roxane name. You are correct in they always start with 54. I have been on the 30 mg for quite a while now and there really in no Brand Name for those.
I currently get 15mg oxycodone IR and used to be rx'd 30mg IR oxycodone (about 2-3 months ago) and on the bottle for both, they said generic substitution for roxicodone 15mg or 30mg tabs xano, which is short for xanodyne pharm, a part of roxane or vice versa. My rx is written as oxycodone 15mg, etc though, but everytime it says generic for roxicodone. Roxane/Xanodyne must have been the originl producer of these stregths even if it is no lonher available. I know they still make roxicodone 5mg per 5ml solution (syrup) as I just recieved an 8oz. bottle and another written rx for dental pain. Walgreens (which I usually refuse to use was the only pharmacy out of about 10 I called who carried the stuff) did not have an 8 oz. quantity of the mallinckrodt generic the first time so filled it with the roxicodone brand. The next time m dentist wrote me an rx, they had ordered more of the generic so I got the generic mallk'dt. oxycodone 5mg/5ml oral solution. To be fair and honest, they tasted the same, had the exact same effect (actually, the mall version seemed to make me more sedated feeling but it could have been lack of sleep) and I really noticed little if any difference so mall'kt is doing a decent job there anyway. I have noticed that some of their narcotic/apap combos are lousy and myslef have noticed that thier percocet 5/325mg and norco 10/325mg seem to lack a bit in potency compared to their generic and brand counterparts and have heard negative things about their generic methadone. Interesting if it will ever become enough of an issue with patient complaints for changes to be enforced.
PDX
Jeck You are correct Did Roxane sell that oxy IR to another company for it comes up other than Roxanne. Is it Xanodyne? For as long as the 30 mg Oycodone IR have been on the market I have been prescribed them. I have never gotten those. Hmm. That goes to show you that so many more in this room have more knowledge than a lot of Pharmacist's on certain issues.lol I asked 2 pharmacists and they both told me the same thing, that there afre only 3 Oxycodone IR's, well they obviously are wrong
gcdylan, it is interesting that you point that out.Neither my doctor nor pharmacy (quite a few pharmacies actually) either told me that 30mg oxycodone IR did not exist or that they had never heard of it. I was taking 2 15mg Oxycodone IR for b/t pain and asked my dr. about the 30mg to be more efficient. He didnt think it existed until he looked it up on his palm pilot med list. Same with percocet 10/325, he was only aware of the 10/650 version back when I wsa using 10mg percs for b/t pain and was concerned about my daily apap intake as I was taking two at once sometimes multiple times daily to augment my 40mg (now 80mg) oxycontin dose. My doctors response in oth situations was patient one, dr. zero. Also I once at rite-aid had a pharmacist swear that there was no form of oxycodone 30mg IR and filled my script with #360 oxy 5mg IR instead of the #60 30mg tablets as written. It just said to take 6 at once instead of one 30mg tablet, talk about inefficiency! I called around to several pharms in Portland, OR and only one ( a mom and pop shop) carried them, suprising. Not even the pharmacy at a hospital/cancer center carried them and they usually carry every narcotic know to man
. Any Roxane and xanodyne are the same company, I'm speculating that roxane was bought out and/or merged with xanodyne and kept the xanodyne name, even though the majority of their P.M. products begin with a rox... Just re4cently, I printed out a list of all the common imprints from this site and showed it to my doc, he was in awe of how many different formulations and manufacturers exist, just for oxycodone, hydrocodone, propoxyphene, morphine, and tramadol. Also, I am wondering why this list does not include hydromorphone products? Anway I'll wrap it up now but as a note to the original post, both my doctor and a pharmacist at safeway have had complaints as to mallincrodt products not being as effective as thier brand or other generic counterparts. Same with the teva and impax/dava generics of oxycontin. My doc writes D.A.W. on all my rx's now so I can get the brand on my pain meds and have insurance pay for it. Same co-pay, much better product.
Cheers
PDX
Interesting, I use Safeway too, and had the exact same thing happen to me when I was on Oxycontin, several years ago. The Pharmacist (head guy, that did the ordering) didn't know the 15 or 30 mg existed until he looked them up when I came in to have a script filled. A script that I had to have my doctor look up the meds, because he didn't know either. Hmmm, makes you wonder sometimes. What did we do before the internet???
Director
In 2005 Xanodyne acquired aaiPharma, which owned the rights to several pharmaceutical drugs. One of the drugs was Roxicodone, which aaiPharma acquired the rights to from Elan Corporation LLC in 2003. And finally, lol, Elan Corporation acquired the rights to Roxicodone from Boehringer Ingelheim Roxane in 2001.
** in all instances, acquired means paid a boat load of money for**
Thank you for the links, Solo5010. I still can't keep straight who makes what, for who, and who distributes for who, and under what name, etc.
gtrplayer
The easiest way to tell that I use, is to look at the full Prescribing Information. It usually tells at the very bottom of it who manufacturers the meds,who is the distributor and who markets it, if other than that company. As you know DailyMed has a huge selection of Prescribing Information sheets, so that helps when you are trying to figure out who makes a particular med.
Ive been taking percocet for a bad back for over a year anyway I went to a different pharmacy this time and they gave me the m generic . My body is going thru withdraw and they are horrible. Now I'm stuck with this for 27 more days. Never again will I make this mistake. I hope others will read this and watch what they get before they leave the pharmacy.
I've never noticed a difference in any of the generics or brand name and i've taken them all......By law all generics must contain the same amount of the active drug, possess the same rate of absorbtion in the body, the only lee way they have is on fillers/colors/shapes. Otherwise it's the exact same meds. This is Federal Law. You might experience something different with a generic because of a dye they used, or a binder in the tablet, but otherwise i think it's psychosomatic...i.e all in your head....Just my thoughts, best of luck
Ray
Ray, Apparently you haven't been keeping up with current events. Read the posts on this thread. You will find the Mackies have about a 99.9% negative approval rating. This is not a case of psychosomatic suggestion. The vast majority of people who post here need their medication in order to live some semblance of a normal life. Just like the poor guy who is stuck 27 days short of a new prescription because his CII medication is as useless as a bottle of generic tylenol. I myself have been a victim of this fraud.....and I do mean fraud..as have numerous individuals with whom I have breached the subject. And by the way, There is either a 10 or 20 percent variance in the formulation of generic medications allowed by law. Mackie apparently takes full advantage of this loophole in order to produce their cheap, ragged, and ineffective product.
Stinson
(edited)
This is true ad I have found Malli. hydrocodone probably 10-15% as ineffective
PaWl WaLl
Does anyone know of a pharmacy that doesn't use Mallickrodt?
It seems like they all do now. I don't know about the mom and pop pharmacies though.
Wal-mart used to have Amide and Roxanne but sadly they too have switched to Mallinckrodt. When asked if they could change manufacturers you'd think I was committing a crime.
For stimulants (Ritalin/Adderall/Dexedrine), mallinckrodt has the paradoxical reputation of being the best generic, which is interesting if you consider how loathed they are among people prescribed painkillers.
I'm just saying that personally i can't tell ANY difference....and i've had just about everthing made by everyone in the book...
Ray
Remember: Just do it.. EVERY PILL EVERY DAY
It is true, they really don't work, they give a queasy feeling and headache too. It is not psychosomatic because I have been a pain patient for years and whenever I first got these I thought there was something wrong with my diet or something and then when the whole script kept not working I did some research into why different ones look different and discovered it was a different brand and have since avoided it most of the time except for giving it a chance a couple more times cuz it seemed so unlikely. I have never had problems with any other ones not working. It is not like I regularly expect my pain medication not to work. I really think there is some major scam going on here and it is a shame that all pharmacists and doctors because they are not pain patients (or addicts) don't believe it. It is really true. There is a huge difference. I am stuck with these now cuz they are the only ones I could get, and I have had a headache and general malaise and feeling very tense for the last 3 days I have been taking them and very little pain relief. I usually have Watson and this doesn't happen. I am really mad that to get rid of my pain I have to take something that gives me a headache!!
I'm not really sure about this. Watson has always seemed to work better for me than any other, and I have always hated Mallinckrodt.
Whenever I had Watson hydrocodone, one tab would work fine for the pain. But, if I was taking Mallinckrodt I'd have to take 2-3 for the same effect.
From my experience, a 10mg Watson Oxycodone tab seemed to work better and longer than two 7.5 Oxycodone tabs made by Mallinckrodt- and the same with Hydrocodone.
I also always preferred 7.5mg of Watson Hydro. or Oxy. to 10mg of the Mallinckrodt brand Oxy. or Hydro.
But I have no idea if it was an actually difference in the ingredients, an issue of freshness, or if it was just all in my head.
Oxycodone and Hydrocodone are the only two types of medication I have tried from both companies, so other than those, I have no idea.
I've had to deal with extreme chronic low back pain for over twenty years now. One of the oddities that I have noticed is that Mallinckrodt's Hydrocodone is about twice as effect as their competitors such a Watson etc. Even the AMA has confirmed this about their Hydrocodone, I just don't know if it applies to any other meds.
When it comes to Morphine, I prefer Mallinkrodt. Altough, the Watson brand Morphine works just about the same. The brand I HATE when it comes to Morphine is the Endo brand. They don't work at all. I actually go into withdrawals when I'm given them. Unfortunately it seems that in at least the 60mg strength that's the only thing around in my area right now.
Mallie morphine sulfate, they have nt let me down yet.
but believe that any pharmiecetiucal company makes some bad run s on occassion, whether its bad ingredeints or poor quality control during the processing , after my wifes ordeal with Watson s hydrocodone, I won t lay no odds on nothing.
Woodstock
jon dekerguelen Please either supply a link to or copy and paste the information you have read stating that the AMA of all outfits has confirmed that Mallinckrodt makes a Hydrocodone combination product that is twice as effective as other generic products. Im having trouble believing that such a confirmation exists and find this post both questionable and laughable.
I live in South Florida and it's hard to get my 15 mg prescription filled PERIOD. It is a nightmare some months trying to find a pharmacy that has this medication in stock and many times I have to get them from my doctor. Mallinckrodt seems to be the only brand available, with the exception of early August, CVS gave me the Actavis.
In my opinion the Mallinckrodt oxycodone 15 mg work fine for pain relief. This brand might have different products that some people find inferior, the same way I had a negative opinion with the Ethex tablets. Stange that the Ethex liquid version worked very well for me, but the tablets seemed to not work at all!
I have been Rxed OxycodoneIR in the 30 mg strength for 2.5 years now, the daily Rxed quantity reached as high as 10 p/d. During that time I tried 3-4 different manufacturers but Mallinckrodt was the most often dispensed brand. In this strength and formulation I wasn't able to tell any difference in time of onset, duration, perceived "strength" or amount/type of side effects between any of the manufacturers. If I were to be given a double blind test on these pills I'd probably score them all as equal to the ones made by Mallinckrodt . . . Q
Does anyone know where their medications are manufactured?
Does anyone know what types and amounts of 'fillers' are used in their generic medications?
Does anyone keep a list of any side-effects thy've had that they relate exclusively to the intake of this manufacturer's medications?
Does anyone know about their 'Quality Control standards & procedures?
Is there anyone available that is an ex-employee of this company that can tell the facts about their procedures and manufacture?....
There are obviously (in my opinion) some major issues with their generic substitutes, but without the items above, it's only speculation....
Mallinckrodt is HQ'd in Hazelwood, MO and have a manufacturing plant in Hobart,NY there parent company is Covidien. The types of inactive ingredients are listed in every prescribing information leaflet which can be obtained on there website, the quantities arent listed but I do believe they are included in the paper work filed with the FDA ie. ANDA, NDA. Quality Control is going to be a &*&? shoot just like it was with ethex, actavis and caraco. They have rules set in place and testing they are suppose to do (first, last and a certain amount inbetween out of each batch I do believe) but the under staffed FDA inspectors cant be everywhere at one time making sure they are doing all of the quality tests and at the right time. I personally dont think a company of this size and caliber would intentionally jepordize quality just to make an extra buck but there are always going to be lazy production workers that will try to squeeze one last batch of pills out of the bottom of the barrel/bag/can/tray/bin of active ingredient before shift change, breaks, lunch, restroom, etc.
good answer...I can't add much except for an exclusive side effect: hiccups. It is so annoying. Someone I know has similar experience except that the hiccups are only an issue if they smoke a cigarette. Neither of us have the side effect with other brands of the instant release oxycodone. I also recall noting increased urinary difficulty the last time I filled my Rx at a M carrying pharmacy...
hi, i,m looking at my bottle of hydro 10/325 and the mfg reads...AMNEA ...a,m i reading this right? is this one a good one?
probably..i have a couple friends who use this brand
Will give you the lot #, the warehouse distributer, an the pharmicetiucal manufactor merely by asking them.
Woodstock
















Good question re Mallinckrodt.
Mallinckrodt is one of the worlds largest manufactures. Additionally, they are also one of the cheapest (cost wise) manufactures out which is why they are so popular (as well as the fact that they offer such a wide range of drugs).
Personally, i have mixed feelings about their products, and i have noticed that some of their generics seem better than other generics of theirs.
Because of their affordableness and availability, i would recommend that no one write them off before they have given them a chance but yes you are correct that the general consensus (especially on their pain medicines like; hydrocodone, oxycodone, darvon, et cetera) is that they are not as good.
all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.