June 15, 2006 - 3:45am
I've seen a couple of people ask about comparison of one opioid against another and came up with a sample list. I didn't want to lose it and wanted it shared so hopefully this will be a good place as a repository. If there are any mistakes or additions please feel free to add.
This is just a quick comparison so no quoting, as it is only single sourced. Also amounts shown are only for comparison in relation to each other.
|
||||
|---|---|---|---|---|
| Opioid | Strength (Codeine) | Equivalent Dose (30 mg codeine) | Strength (Morphine) | Equivalent Dose (10 mg morphine mg) |
| Aspirin | 1/36 | 1080 mg | 1/360 | 3600 mg |
| Difusinal | 1/16 | 480 mg | 1/160 | 1600 mg |
| Dextropropoxyphene | 1/4 | 120 mg | 1/40 | 400 mg |
| Codeine | 1 | 30 mg | 1/10 | 100 mg |
| Tramadol | 1 | 30 mg | 1/10 | 100 mg |
| Anileridine | 2.5 | 12 mg | 1/4 | 40 mg |
| Demerol | 3.6 | 8.3 mg | .36 | 27.8 mg |
| Hydrocodone | 6 | 5 mg | .6 | 16.67 mg |
| Morphine | 10 | 3 mg | 1 | 10 mg |
| Oxycodone | 15-20 | 1.5-2 mg | 1.5-2 | 4.5-6 mg |
| Morphine IV/IM | 40 | .75 mg | 4 | 2.5 mg |
| Hydromorphone | 50 | .6 mg | 5 | 2 mg |
| Oxymorphone | 70 | 0.4 mg | 7 | 1.4 mg |
| Levorphanol | 80 | 0.26 mg | 8 | .8 mg |
| Buprenorphine | 400 | 0.075 mg | 40 | .25 mg |
| Fentanyl | 500-1000 | 0.03-0.06 mg | 50-100 | 0.1-0.2 mg |
| Carfentanyl*** | 1,000,000 | 30 pcg | 100,000 | 100 pcg |
***Used only in sedating large animals.
Sources:
June 15, 2006 - 6:50am
#2
He says they are in
He says they are in comparison to each other, so I would 'guess' that this list is only (semi-)accurate in a person who is naive.
It does however give comparisons that might be useful to anyone.
June 15, 2006 - 2:50pm
#3
where does dihydrocodiene
where does dihydrocodiene fit in? i have always had a hard time finding its strentgh to ratio.
i know on rx indications it often states "for moderate to severe or moderate severe pain"
June 15, 2006 - 4:59pm
#4
Opioid Comparison
Thanks for the post, Rawoody. Your information is very interesting and will help readers wanting to compare the relative strengths of various opioids.
We put an excerpt of your post on the front page.
November 1, 2006 - 4:10am
#5
Dihydrocodeine
Same potency as codeine.
Source:
http://en.wikipedia.org/wiki/Dihydrocodeine
Also as an example to make sure things are clear:
| Hydrocodone | 6 | 5 mg | .6 | 16.67 mg |
Using hydrocodone as an example, the 6 refers to the potency as compared to codeine. The second number refers to how much hydrocodone is needed to be equivalent to 30 mg of codeine. THe 3rd number(.6) and the 4th is the same as the first 2 but in relation to 10 mg of morphine.
June 16, 2006 - 8:32am
#6
one last question. do you
one last question. do you have any idea where levorphanol into the chart. i have had a difficult time researching this medicine. i understand that it is an inexpensive medicine and from the best i can tell it is a morphine dirivitive but i have also read things saying that it was similar to methadone. needless to say i am very confused. any help is appreciated.
June 17, 2006 - 3:25am
#7
Nope... not yet.... will try
Nope... not yet.... will try and if I do.. I'll post it.
June 28, 2006 - 11:33pm
#8
would Carfentanyl be the
would Carfentanyl be the same as ketamine? or is that a totally different thing
June 29, 2006 - 8:26am
#9
Carfentanyl vs. ketamine
Carfentanyl is completely different from ketamine. While ketamine is widely used on animals as well, it is also used in humans for anaesthesia and even treating migraines. Carfentanyl, on the other hand, is way too potent to be considered for human use, therefore is only used in veterinary practice to sedate large animals.
July 1, 2006 - 5:50am
#10
Phisher
Levorphanol is listed as 8x as potent as morphine.
Source:
http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00764.txt
Anileridine = 2.5x Meperidine and .25x morphine
Source:
http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/anileridine.html
Dextropropoxyphene (Darvon) .25-.33x codeine and approx 9x ASA
Source:
http://www.dea.gov/pubs/abuse/4-narc.htm
Buprenophine is approx 40x Morphine
Source:
July 1, 2006 - 6:00am
#11
outstanding work as usual
outstanding work as usual rawoody, thanks alot! i have had a time trying to find any good info on the med. it is odd b/c not alot of people seem to be rx'ed to it yet it is so cheap. for one reason or another doctors dont choose it often and i was just curious its potency in relation to other drugs in that class.
July 8, 2006 - 3:28am
#12
Bump
I've asked David to update the chart to reflect the most recent additions... note that I added aspirin to show much stronger opoids are in comparison (Thought it might be useful.)
July 15, 2006 - 3:42am
#13
Pentazocine
Pentazocine (Talwin) is considered to be 1/3 to 1/6 (ave. 1/4) as potent as morphine.
Source:
August 3, 2006 - 4:14pm
#14
i thought this was
i thought this was interesting
http://www.oqp.med.va.gov/cpg/cot/G/OT_Med.pdf
though i still think that rawoodys is more representative of the majority of the tables i have seen.
also his is much more comprehensive but nevertheless it is interesting.
all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.
August 31, 2006 - 2:38am
#15
^=bump=^
Keeping this close to the top (or atleast on the first page) will probably help answer many questions. And keep it from getting buried.
September 19, 2006 - 4:45am
#16
Bump
Bump
September 19, 2006 - 6:50am
#17
Bump
We added a permanent link to the menu item Health, Drug Topics.
Rawoody's chart is in the subsection All You've Ever Wanted to Know About ....
Would a 'sticky' post at the top of this forum (Discussion of Prescription and OTC Meds) be better?
September 19, 2006 - 11:21am
#18
I think a 'sticky' would
I think a 'sticky' would benefit many users. Between the link in the 'Health, Drug Topics' and a sticky post, this thread would be hard to miss.
I believe that some users never venture into the 'Health, Drug Topics' menu.
It would also benefit those looking for this info, but do not use the search feature for whatever reason. And more often those searching for this info, but do not necessarily know the proper search terms they are looking for or need to use.
March 15, 2007 - 4:15am
#19
what about morphine or fentanyl
can i ask a?
how many 30mg codeine would be = to 20mg hydrocodone
<<<,,,<,HaV0K..>>..>..>p3aCe...ONE LUV.
March 15, 2007 - 7:59am
#20
Sorry, you're going to have
June 10, 2007 - 12:17pm
#21
Accuracy of Demerol Strength
i've done a little bit of reaseach and i'm finding that your demerol strengh might be off. please correct me if i'm wrong
http://www.uofapain.med.ualberta.ca/images/UGPainlecture1dec2006.jpg
http://www.uofapain.med.ualberta.ca/opioidconversion.htm
btw, this is a really nice site
[EDIT]
oh, i see where the conversion came from, you were using IV rather than oran Demerol.
It seems that you switch between oral and IV/IM for your morphine comparisons.
June 25, 2007 - 5:01pm
#22
thanks, that has already
thanks, that has already been a big help!
June 26, 2007 - 11:30am
#23
what about methadone acute and chronic?
what about methadone acute and chronic?
*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*
June 26, 2007 - 11:32am
#24
When is methadone used in an
When is methadone used in an acute setting?
I'm assuming the "acute" part means "IV"
June 26, 2007 - 12:57pm
#25
i am still havin problems
i am still havin problems convertin this (guess i shoulda payed more attention in math class)like how many mg's of codiene would i have to take to equal like 1-10 mg lortab.......
June 26, 2007 - 1:29pm
#26
definately not
IV means intraveinously. acute is for short time period, chronic is for long term use since the half life builds rapidly, personally I know where it fits in the chart but its just not in it and sometimes it varies so much from person to person that they might just have not wanted to mess with it.
*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*
June 26, 2007 - 2:00pm
#27
I know.
I know.
But Methadone is not to be a first line analgesic. We've all read about the kid with tooth pain, and the dentist gave him Methadone. I'm not saying it doesn't happen, I'm just saying that it's not a conventional form of acute medicine.
June 26, 2007 - 2:01pm
#28
It's a wonder you got out of
It's a wonder you got out of preschool if can't multiply 6x10=60mg of codiene. ok 4th grade but still.......
*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*
June 26, 2007 - 2:06pm
#29
i didnt hear that one but I
i didnt hear that one but I think it means when you first switch from a less potent narcotic and don't have methadone built up in your system, so when you first start on it you don't have days and days of half-lifes of the drug left in your system like you do once you start a daily regimon for a long period.
*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*
June 26, 2007 - 2:18pm
#30
WOW
wow thanks, that BS in psychology is really payin off huh!
July 2, 2007 - 5:49pm
#31
Methadone
Methadone is used for both actually but the reason why drs use it with chronic pain is because it has a half -life of half.lol. Take 50mg at 8am monday and 8am tuesday there are still 25mg in your body and also it builds and builds this is why alot of ppl take it and say well it dont work but its stronger than hydro and I do think that it is stronger than hydromorphone.
July 11, 2007 - 2:49pm
#32
Oxycodone
why is Oxycodone 15-20 ......why does it vary???
July 11, 2007 - 4:44pm
#33
because of conflicting
because of conflicting information. Some places have oxycodone as 2.0 X as strong as hydrocodone, while others have it at 1.5 X as strong as hydrocodone.
July 11, 2007 - 5:19pm
#34
good info,thanks
good info,thanks
August 17, 2007 - 8:28pm
#35
awesome, like that chart!
1 question, or where is the Methadone (dolophine)? As it is still can be prescribed 4 pain as well. Several of my sources say that
Levomethadyl Acetate ,Buprenorphine & Methadone as different drugs.
KnightMetal
- I am not an MD
- I know by experience only
- Please do not take advise from anyone, consult YOUR MD 1st
(DONT GET ME WRONG, I AM NOT COMPLAINING, I LOVE THIS CHART, I JUST WANT TO KNOW WHERE THEY STAND IN THERE)
November 8, 2007 - 12:56pm
#36
Well this blog is a real
Well this blog is a real encyclopedia concerning drugs. I had a lot to learn here, these informations are very useful specially if we think about people fighting addiction.
Edited by Mod3 - please, no links to commercial enterprises except:
- Pharmaceutical manufacturers
- Pharmaceutical websites like Requip, Chantix etc.
- Websites for consumer drug information, pill images, pill identifiers - for example Drugs.com, Holy Family Memorial Hospital, RXList.com
- Other sites supplying free pharmaceutical and medical information that are approved by us
November 22, 2007 - 9:37am
#37
Very informative drug
Very informative drug comparison chart.
(edited)
November 26, 2007 - 1:03pm
#38
drugs
this is a very good list very good comparison.
Edited by Mod2
February 18, 2008 - 5:56pm
#39
Morphine
So morphine ain't that strong anyway. Maybe it isn't that good you've made this comparison.. people could use it in bad purposes.
_____________
February 18, 2008 - 6:05pm
#40
People can use spoons for
People can use spoons for bad purposes too, but I still like to eat ice cream with them. What do you mean by "morphine aint that strong anyway"?
March 21, 2008 - 3:13pm
#41
Real life Opioid Comparison
..It's funny, because I had a colonoscopy done last Monday, I know you didn't want to know that, just as much as i didn't' want to have it, but they gave me 20mg versed and 500mcg of fentanyl and I don't feel like it affected me as much as it should have and compared to all the other people i saw everyone was zonked and i was WIDE awake, and it kinda scares me ...and it's also weird that i've not taken either of those drugs extensively, versed once or twice and that was the first time for fentanyl, don't get me wrong, i didn't feel any pain or discomfort during the procedure, but I makes me wonder about anesthesia awareness...God, would that be HORRIBLE!!!
Ray
Remember: Just do it.. EVERY PILL EVERY DAY
(edited)
March 21, 2008 - 3:19pm
#42
Reckless methadone prescribing
I went to my FAMILY DOC of like 25 years complaining about migraing headaches....and outta the blue he writes this script for methadone....LOL, I was floored, it worked
..still to this day he hasn't done it again, although i haven't seen him in years, he dropped me as a patient when he found out I was HIV+and the was in 1999 (YES, it still happens, this is rural ky)......Ray
Remember: Just do it.. EVERY PILL EVERY DAY
March 21, 2008 - 5:13pm
#43
tolerance and response
It all depends on other drugs you're taking, your particular response to the drug, the effects of the other drugs on the narcotics, and just how they affect you and how you metabolize them...something i might take might put someone else underground....It's subjective as a function of tolerance.
Ray
Remember: Just do it.. EVERY PILL EVERY DAY
July 18, 2008 - 9:06pm
#44
Yeah, since you're not what
Yeah, since you're not what they call "opiate naive" they affected you less. Your receptors need a certain amount of any opiate (tolerance), so that's why you were probably far and away the least affected.
If there is a next time, let them know that you aren't sedated easily, they'll adjust the dosage. If worse comes to worse, act like you're panicking and don't feel anything. haha.
Edit: Wow, I just noticed this was a few months old. Apologies.
July 21, 2008 - 3:35pm
#45
Drug doses
Just my opinion, but I can't say I believe either of the drug doses mentioned in the above post for a Colonoscopy!!! Not only is 20 mg Versed high, but 500 mcg of Fentanyl is out of the ballpark. Who are you trying to BS Ray?
November 20, 2008 - 12:12am
#46
Agree with director
There is no way anyone can take 500mg of Fentanyl!!!
Keep in mind I am not a; doctor, a pharmacist, a counselor, or any professional for that matter. My posts are not meant for medical advice, nor should you use it that way. I am simply a college student/ guinnea pig/ drug addict. Thanks for your concern.
November 20, 2008 - 1:20am
#47
Director said mcg which is
Director said mcg which is micrograms not mg. 500mg of fentanyl will kill any breathing animal on this planet regardless of tolerance. 500mcg on the other hand if it is in patch form and 500mg per hour wouldnt be so deadly as long as someone has built up a tolerance over a very very long time but i have never seen anyone prescribed that much anyway. The most i have ever seen anyone prescribed was 150mcg/hour with a breakthrough med which is still a lot. but i think if someone has a sufficient tolerance and has abused opiates long enough they could survive 500mcg/hour but very very few people could
November 20, 2008 - 12:44pm
#48
Maybe I'm misunderstanding
Maybe I'm misunderstanding you, but... I wear the 100mcg patches, I take 8 - 12mg dillaudid for mild to moderate BTP, and I take 800mcg fentynal x*#&ers for mod. to severe BTP. When I take the x*#&ers which disolve within 10 min. I am taking 900mcg in that hour. I am not only still in pain with this dose (although more tolerable) but I can still drive and do all my ADL's. I have obviously built a tolerence, but have never abused any of my meds. I actually have left overs every month. My perscriptions are filled to get 120 x*#&ers and 120 dilladid per month with both written for every 4-6 nours. Now there are days that I use only 1-2 and days where I use 4-6, at 800mcg each plus the 100mcg patch, thats alot of fentynal but I just want to clarify that not everyone on these amounts are abusing their meds. Maybe I'm being a little sensetive today, or I just took it wrong and I'm sorry if I did, but I felt defensive when I read "abused opiates long enough" and the the dose was almost half what I'm taking.
November 20, 2008 - 12:53pm
#49
I'm sorry I do see now that
I'm sorry I do see now that you said "if someone has a sufficient tolerance" but you put and abused, This must of been what set me off. Sorry again, maybe I shouldn't read these posts when I'm irritable. I know alot of people abuse and that has to be addressed when discussing tolerence. I had to go to a dermatologist yesterday and gave my list of meds, mind you I'm petite at 5'3'' and 120lbs, only 36yo, but, when they read my list and say "I highly doubt you take all that yourself, you wouldn't be walking", it ticks me off. I wanted to say "If I ate all the food your fat ... ate I wouldn't be walking". Again, I'm sorry for getting defensive with you, everyone here is very supportive of eachother and I just started typing without re-reading or thinking. Sorry.
edited
November 20, 2008 - 1:30pm
#50
lol your right they should
lol your right they should not make comments like that. They dont know the pain you are in and your tolerance levels.
nice Rawoody! that is a very good list and looks pretty accurate. i know it is hard to put togethter a list since they are all slightly different. i understand that it is equal doses but is this one for someone who is opiate niave or tolereant?