Opioid Comparison
I've seen a couple of people ask about comparison of one opioid against another and came up with a sample list. I didn't want to lose it and wanted it shared so hopefully this will be a good place as a repository. If there are any mistakes or additions please feel free to add.
This is just a quick comparison so no quoting, as it is only single sourced. Also amounts shown are only for comparison in relation to each other.
|
||||
|---|---|---|---|---|
| Opioid | Strength (Codeine) | Equivalent Dose (30 mg codeine) | Strength (Morphine) | Equivalent Dose (10 mg morphine mg) |
| Aspirin | 1/36 | 1080 mg | 1/360 | 3600 mg |
| Difusinal | 1/16 | 480 mg | 1/160 | 1600 mg |
| Dextropropoxyphene | 1/4 | 120 mg | 1/40 | 400 mg |
| Codeine | 1 | 30 mg | 1/10 | 100 mg |
| Tramadol | 1 | 30 mg | 1/10 | 100 mg |
| Anileridine | 2.5 | 12 mg | 1/4 | 40 mg |
| Demerol | 3.6 | 8.3 mg | .36 | 27.8 mg |
| Hydrocodone | 6 | 5 mg | .6 | 16.67 mg |
| Morphine | 10 | 3 mg | 1 | 10 mg |
| Oxycodone | 15-20 | 1.5-2 mg | 1.5-2 | 4.5-6 mg |
| Morphine IV/IM | 40 | .75 mg | 4 | 2.5 mg |
| Hydromorphone | 50 | .6 mg | 5 | 2 mg |
| Oxymorphone | 70 | 0.4 mg | 7 | 1.4 mg |
| Levorphanol | 80 | 0.26 mg | 8 | .8 mg |
| Buprenorphine | 400 | 0.075 mg | 40 | .25 mg |
| Fentanyl | 500-1000 | 0.03-0.06 mg | 50-100 | 0.1-0.2 mg |
| Carfentanyl*** | 1,000,000 | 30 pcg | 100,000 | 100 pcg |
***Used only in sedating large animals.
Sources:
He says they are in comparison to each other, so I would 'guess' that this list is only (semi-)accurate in a person who is naive.
It does however give comparisons that might be useful to anyone.
where does dihydrocodiene fit in? i have always had a hard time finding its strentgh to ratio.
i know on rx indications it often states "for moderate to severe or moderate severe pain"
Thanks for the post, Rawoody. Your information is very interesting and will help readers wanting to compare the relative strengths of various opioids.
We put an excerpt of your post on the front page.
Same potency as codeine.
Source:
http://en.wikipedia.org/wiki/Dihydrocodeine
Also as an example to make sure things are clear:
| Hydrocodone | 6 | 5 mg | .6 | 16.67 mg |
Using hydrocodone as an example, the 6 refers to the potency as compared to codeine. The second number refers to how much hydrocodone is needed to be equivalent to 30 mg of codeine. THe 3rd number(.6) and the 4th is the same as the first 2 but in relation to 10 mg of morphine.
one last question. do you have any idea where levorphanol into the chart. i have had a difficult time researching this medicine. i understand that it is an inexpensive medicine and from the best i can tell it is a morphine dirivitive but i have also read things saying that it was similar to methadone. needless to say i am very confused. any help is appreciated.
Nope... not yet.... will try and if I do.. I'll post it.
would Carfentanyl be the same as ketamine? or is that a totally different thing
Carfentanyl is completely different from ketamine. While ketamine is widely used on animals as well, it is also used in humans for anaesthesia and even treating migraines. Carfentanyl, on the other hand, is way too potent to be considered for human use, therefore is only used in veterinary practice to sedate large animals.
Levorphanol is listed as 8x as potent as morphine.
Source:
http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00764.txt
Anileridine = 2.5x Meperidine and .25x morphine
Source:
http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/anileridine.html
Dextropropoxyphene (Darvon) .25-.33x codeine and approx 9x ASA
Source:
http://www.dea.gov/pubs/abuse/4-narc.htm
Buprenophine is approx 40x Morphine
Source:
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nice Rawoody! that is a very good list and looks pretty accurate. i know it is hard to put togethter a list since they are all slightly different. i understand that it is equal doses but is this one for someone who is opiate niave or tolereant?