Percocet vs. Endocet
I am somewhat curious about Percocet brand name oxycodone/APAP and Endocet generic percocet. Are they made by the same manufacturer? I have been rx'd 5/325, 7.5/500 and 10/650 strength Percocet tablets. When filled at my pharmacy, they were dispensed as Endocet in the same strengths. When I filled my last Rx, they were out of generic and i was dispensed brand name Percocet. On the label, i had the same manfacturer listed as Endo Pharm. Also, the Percocet pills, with the exception of the 5/325 were the same shape color, and size, had the same score marks or beveled edges and the same 7.5 or 10 imprinted in the same manner as the generic endocet pills. The only difference is insteadof Percocet they say E796 or E797 and the 5/325mg strength is the same size and has the same score and bevel marks as the brand 5/325 only it is white instead of blue and has Endo 602 imprinted instead of Percocet 5.
Are these generics the exact same thing as the brand name, and if so, why is the brand so much more expensive if it produced by the same manufacturer in the same manner?
Thanks
JeckPDX
I have been taking oxycodone for more than 2 years. Last week my pharmacy was out of oxycodone and filled my perscription with Endocet. From the very start I did not feel like I was getting the same pain relief. I ended up sleeping at least 6 extra hours each day. By the end of the week I was in severe pain and then proceeded to get flu like symptoms. Today is the first day I have felt a bit better. I spoke to my physician last week in the midst of the turmoil and he told me to tell the pharmacist they had to fill my perscription with oxycodone and not endocet. In my particular case, Endocet is definitely not the same strength as oxycodone.
I wanted to write this because I am sure this has to have happened to others in the past. Let me know and Good Luck to all.
Endocet IS Oxycodone!!!
Endocet is a brand name, with Oxycodone being the active pain killing opiate. Endocet is available in many of the same strengths as percocet but with less APAP (tylenol).
The only real difference is the manufacturer.
I've recently kicked a long long bad habit with pain medication because of an injury. I do not have an official degree in pharmacutecals nor am I a doctor, but I do have great interest in pharmacutecals and much experience.
Oxycodone is generic for endocet, percocet, and oxycontin.
The reason you may feel different is because it is all in your head, and you may be developing a tolerance. But there is no difference in the two.
the symptoms you described as being flu like sounds like w/d symptoms to me. In no expert but from what I understand that appears to be the case. Hope you resolved your issue.
Sorry, but you are wrong. There are differences with generic brands. I also take Percocet for chronic pain. When my pharmacy switched to Endocet instead of the Watson brand I was used to taking, it not only did not work as well, but I also had an increase in side effects. I had to talk with my doctor AND pharmacist to figure out the problem. (had no thoughts at the time that it had ANYTHING to do with the med change). Turns out my pharmacist and doc had both heard of some people getting better relief with one generic brand versus another. I belong to a group for chronic pain and many members have experienced this as well.
I found this article awhile back that might help shed some light on this topic.
It discusses the "20% variance" allowed in the bioequivalence of generic drugs, that many consumers are unaware of.
The first part of the article pertains to the regulatory aspects of the generic approval process and explains allowable differences. With the second half titled: "Examples from the world of consumer experience" dealing with individual cases, much like those expressed in this thread and others.
It is an interesting article and worth the read.
ok im not going to get into the other debate about certain generics beind better than others as IMO, its totally placebo/users body chemistry or something along those lines...generics follow VERY strict regulations and there is no way one generic could be significantly different/stronger/whatever than another generic or even the name brand...atleast when its taken as prescribed. im not saying its total BS or that you guys are liars, im just saying its not the actual pill/company or anything, its YOUR body/opinion/mind so dont assume you're right or that generics x*#& or something.
ANYWAYS, about the endocet vs. percocet thing:
BOTH forms of this oxycodone/apap combination drug are made by ENDO Pharms....there is NO difference except for the fact that the imprints differ and some of the strengths and oxy/apap ratios are different. However, this is NOT the reason why the same manufacturer produces both a name brand and a generic version. They also make a generic version in an attempt to help bring back revenue that is lost once the patent runs out on the original name brand drug and many other rival companies begin to produce generics. Instead of losing basically ALL their sales due to most people getting generics over a name brand once one is available, the pharm company(ENDO in this case w/percocet) will also put out a generic version of their own product in order to compete with the other generic manufactures...sometimes the first generic to come out is made by the name brand company which is what happened with ENDO; Percocet and then came ENDOCET.
pretty smart eh?
BTW, this is STRICTLY my opinion, but i have found NO real difference between the brand name percocet 10/325, the ENDOCET 10/325, or the watson 10/325....in fact, if anything i like the generics better....they're cheaper 
OH, i didnt see the post directly above mine that i just posted.
that site is wrong, i am sorry.
call up the FDA and ask about generic regulations. you ARE WRONG about the 20% thing, but im not trying to prove you wrong or anything i just dont want you to mislead people into thinking that kinda stuff is true....maybe in other countries, but not in the USA. i think all drugs(generics included) follow the same strict and stringent guidlines....they even have to absorb similiarly, last the same amount of time, reach the same peak plasma levels, etc, etc, etc....i could go on and on, but i'd rather the people who disagree do some research and find out the truth on their own.
AGAIN, i am NOT saying one brand of medicine cant work better than another FOR YOU as an INDIVIDUAL, but its strictly your body chemistry, mind, etc.....because belive it or not, against everything i just said above lol, i find the Mallinckrodt brand of hydrocodone/apap products to be inferior in MANY aspects to nearly every other brand i have tried. there is no reason or rhyme behind this, it is just my personal preference and past experiences that give me this opnion.
but please understand that the guy above me is incorrect about how different generics can be.....any difference is either incorrect storage/transport of the medication OR your individual body/preferences.
hope this helps
-ktx49
This is taken from Wikipedia
"Bioequivalence is a term in pharmacokinetics used to assess the expected in vivo
biological equivalence of two proprietary preparations of a drug. If
two products are said to be bioequivalent it means that they would be
expected to be, for all intents and purposes, the same."
The "Regulatory Definition" for the United States is listed as:
"The FDA considers two products bioequivalent if the 90% CI of the relative mean Cmax, AUC(0-t) and AUC(0-∞) of the test (e.g. generic formulation) to reference (e.g. innovator brand formulation) should be within 80.00% to 125.00% in the fasting state. Although there are a few exceptions, generally a bioequivalent comparison of Test to Reference formulations also requires administration after an appropriate meal at a specified time before taking the drug, a so-called "fed" or "food-effect" study. A food-effect study requires the same statistical evaluation as the fasting study, described above."
The 20% thing doesn't seem so far off now. I guess I won't have to call the FDA.
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Hi there,
Believe it or not, Endocet pills are made by the exact manufacturer as Percocet, Endo Pharmaceuticals. So therefore, Endocet is technically a brand name. The only reason the company manufacturers two different brand named Oxycodone/Acetaminophen pills is because they vary slightly both by Oxycodone/Acetaminophen dosage and color.
Percocet Oxycodone/Acetaminophen combonations:
2.5/325mg (Pink colored, oval) - Imprinted with PERCOCET - 2.5
5.0/325mg (Blue colored, round) - Imprinted with PERCOCET - 5
7.5/325mg (Peach colored, oval) - Imprinted with PERCOCET - 7.5/325
7.5/500mg (Peach colored, oblong) Imprinted with PERCOCET - 7.5
10.0/325mg (Yellow colored, oblong) - Imprinted with PERCOCET - 10/325
10.0/650mg (Yellow colored, oval) - Imprinted with PERCOCET - 10
Now compare those with the Endocet Oxycodone/Acetaminophen combonations:
5.0/325mg (White colored, round) - Imprinted with Endo602
7.5/325mg (Peach colored, oblong) - Imprinted with E700 - 7.5/325
7.5/500mg (Peach colored, oblong) - Imprinted with E796 - 7.5
10.0/325mg (Yellow colored, oval) - Imprinted with E712 - 10/325
10.0/650mg (Yellow colored, oval) - Imprinted with E797 - 10
As far as potency, at least with Hydrocodone/Acetaminophen pills), I have seen about 98% of people preferring the Watson Generic brand of the 10/325mg (Instead of brand named Norco) and 10/500mg (Instead of brand named Lortab). The people that prefer these generics seem to think that they are stronger, and perhaps they are; but by law, all generics must contain the exact same active ingredients as their brand name equivalents, it's just the binders and fillers that can be messed around with a bit. So as far as Percocet and Endocet being the same potency, by law and chemical equivalency, yes they are, but how your body reacts to one pill may be different than how it does for another. HTH!