September 9, 2007 - 12:24pm
Hello all!
i have a question about my situation with these meds. I take 40 mg of methadone daily for chronic pain, and am also perscribed Oxycodone 30 mg for breakthrough. My prob is
that i recently switched to MS for breakthrough but i can not even feal it. It does absolutely nothing for my pain etc..
Can anyone explain this? I know we have a few docs on the site, or anyone with an explanation..
Thanks guys..
September 9, 2007 - 12:42pm
#2
By MS, I assume you mean
By MS, I assume you mean MS-Contin which is an extended release morphine product. Roxicodone is an instant release oxycodone products. So this could have something to do with it. I assume as well that the 30 IR worked and you could feel it? A lot of people, including myself, feel that methadone has a blocking effect on other opiates. Search for blocking dose/methadone.
Check with a licensed MD before you take any suggestions!
September 9, 2007 - 12:45pm
#3
Thanks guys for the info.
Thanks guys for the info. I just dont know why the methadone would block the morphine but not the oxycodone?.
Is there something in there molecular structure that might allow for this?
September 9, 2007 - 5:23pm
#4
King, the OP was probably
King, the OP was probably talking about MSIR. Im also under the impression that Methadone doesnt have the chemical structure to block opiate receptors, but if it does I will stand corrected.
Kittco, if the Oxycodone was working why did your doctor make the switch to MSIR? Also what dose MSIR where you switched to? Its possible your doctor didnt calculate the converion right and switched to a lower dose, IM NOT SAYING THAT HE DID, Im saying its possible, DO NOT increase your dose without your doctors consent. It could also be that you dont tolerate morphine well. When I had morphine IV it didnt do anything for me.
September 9, 2007 - 6:14pm
#5
I wasn't really thinking to
I wasn't really thinking to brightly about it being MSIR since I thought MS was only the trade name for MS-contin, but either way since the question was never answered we really don't know. Here is a gov. link about methadone and it's opiate blocking properties http://www.usdoj.gov/dea/concern/methadone.html This is why I always say for people to look up blocking dose as this is not the case with all methadone use. This also answers your question about chemical structure.
Check with a licensed MD before you take any suggestions!
September 9, 2007 - 6:18pm
#6
yeah, MSIR. 30I dont know
yeah, MSIR. 30
I dont know why it was changed..
thanx for the help though...
September 9, 2007 - 6:51pm
#7
I think if you used a
I think if you used a narcotic dose calculator you wouldve probably seen why you are not getting the same amount of relief from the morphine. 30mg oral morphine is equal to 20 mg oral oxycodone, with a 0% cross tolerance.
September 9, 2007 - 7:00pm
#8
I understand the whole
I understand the whole blocking dose now. When I read your post I thought that you may have been implying that it was an antagonist.
September 9, 2007 - 7:31pm
#9
I dont think you
I dont think you understand.. I get NO relief.. I feel NOTHING from MS,
the Roxicodone, i can feel even a half of a 30 mg workin.
September 9, 2007 - 8:45pm
#10
THEN TELL YOUR DOCTOR
THEN TELL YOUR DOCTOR, WE CAN'T HELP YOU.
Check with a licensed MD before you take any suggestions!
(edited by TeamPharmer)
September 9, 2007 - 9:22pm
#11
You are not really explaining
Quote "I don't think you understand". Perhaps if you tried to explain in more detail, with more specifics it would be easier for folks to "understand"...You were asked several times, but never really answered so folks had to assume one thing or another. You only explain the med as MS. It's really not fair to say folks don't understand, if you don't explain in enough detail.....for anyone to understand....People are trying to understand but with no facts its difficult.
Bottom line is this is a question for your doc, for sure....Tell him you don't feel the MS (whatever MS is, I am not going to assume). I've only had morphine once and did not like it. I hear that orally it is really pretty weak....That said, ONLY your doc can help you with your ?????
thelifeline
September 9, 2007 - 9:43pm
#12
"take 40 mg of methadone
"take 40 mg of methadone daily for chronic pain, and am also perscribed Oxycodone 30 mg for breakthrough. My prob is
that i recently switched to MS for breakthrough but i can not even feal it. It does absolutely nothing for my pain etc.."
I am not a MD, but I dont see why any MD would prescribe METHADONE and OXYCODONE. Being that the METH would "block" the opiates. Anyway, that was my experience, when I was taking METH I could not feel anything else.
__________________________________________
KnightMetal
I am not an MD. I know by experience only. Consult YOUR MD 1st!
September 9, 2007 - 9:48pm
#13
ok, obviously i did a poor
ok, obviously i did a poor job of relaying what i intended to.
My fault. Look, like you say, its a question for my Doc. I will talk to her about it as soon as i can get back in. Its not like i can see her on Sunday, thats why i came to this board......
She is very well respected Pain doc / anesthesiologist, so i dont make a habit of questioning what she does.
Thanx for your help
September 9, 2007 - 9:50pm
#14
Also, MS stands for Morphine
Also, MS stands for Morphine Sulfate.. I thought most would know what that is..
September 9, 2007 - 10:00pm
#15
Yes, most every1 here knows
Yes, most every1 here knows what MS stands 4... 
I did say MOST... Not everyone...
____________________________
KnightMetal
I am not an MD. I know by experience only. Consult YOUR MD 1st!
September 10, 2007 - 9:24am
#16
And MORPHINE SULFATE comes
And MORPHINE SULFATE comes in instant release and extended release, brand named MSIR and MS-Contin. Thanks for clearing that up.
Check with a licensed MD before you take any suggestions!
September 10, 2007 - 12:24pm
#17
What I said I understood
What I said I understood was, the whole blocking dose theory about methadone. Not your problem with your medications.
September 10, 2007 - 3:06pm
#18
Sorry
Hey kittco, I apologize for reacting so defensively....really....I thought MS was the acronym for the MS Contin, but I don't know everything, so MS "could" stand for other things too...I sure as heck know what Morphine Sulphate is, I just wasn't sure that was the only thing MS stood for. My bad. You know how acronyms are....I have a degree that is a BS...God knows that could mean a few things..LOL.
I understand though that the pain you may be in may be making it a bit harder to think of everything......Sorry....Hope you find the right med.
thelifeline
September 10, 2007 - 9:41pm
#19
Lifeline
Thanx bro. Super classy of you. No problem man, it was a Sunday, so thereforwe no way i could get in to see my doc. I just wanted to hear from someone who had had similar situation or had heard of this before.
Thanx for your help,
Peace,
kittco
September 13, 2007 - 9:14pm
#20
Consider...
Switching back if you can
-Makaveli
March 5, 2009 - 8:30am
#21
same position
i am also on methadone and roxicodone 30mg for breakthrough pain. I just saw my dr yesterday and he substituted me 2-30mg MSIR's 5x's a day. He said he was aware that many people felt that 1 MSIR was not equal to 1 30mg roxi, so he doubled my dose. Maybe that would help?
March 5, 2009 - 9:10am
#22
methadone and oxycodone? I
methadone and oxycodone? I thought you had to be way up their on you dose like somewhere in the 70sor 80s to have any blockin affect. Please correct me if Im wrong because Im going to go on methadone soon (a few months) and will still have the oxycodone 30s for pain. The methadone I asked for insted of oxycontin or morphine er. Ive been told that methadone does wonders for pain and your not seeking that (rush) or whatever all day.
Take care all
Kittco,
I am not a doctor, and there is only one person on the board that I know of who may be a doctor. That being said, I can tell you that all drugs affect everyone differently. If the MS is not working for you, talk to your doctor. Some people tolerate morphine very well, while others get no relief from it.
gtrplayer