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Joined: Dec 31 2005
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does the Teva brand have the anti-abuse deterant in them like the Endo Pharm. ones or no? i know the Endo's do and i heard that new companies with OC's are using this as an ingredient so it will not be abused. is this true or just a tale to scare? thanks for ur help

Joined: Aug 26 2005
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need to know 2

I need to know the answer to this ? too. Is there an anti abuse deterant?

sound

Joined: Mar 21 2006
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First of all the Oxycontin

First of all the Oxycontin from Endo Pharmacueticals doesn't contain any anti-abuse fillers. The Teva Oxycontin is made with different fillers. Instead of a fine dust the Teva OC's gel up. Another company Impax Labarotiories has their OC's filled with another gel like filler too.

Teva:....80mg 93/33 imprint

Impax:...80mg G 164 imprint

 
All the other OC's are easily crushed like the brand name Purdue Pharma, with the OC 80 imprint, as well as the Endo Pharmacueticals with the 80mg having the E 710 imprint. Watson's OC also has no gel like fillers. Watson's has the imprint of ABG 80.

 

http://www.pharmer.org/imprints/narcotics#oxy

 

"I am not a medical doctor or expert, any advice given is strictly for the exploration of knowledge and making sure we share what we already know!"

Joined: Mar 21 2006
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User offline. Last seen 1 year 37 weeks ago.
also the OC doesnt become

also the OC doesnt become useless. The oxycodone still remains potent and you would recieve 80mg of oxycodone theoretically all at once. (not smart)

 

"I am not a medical doctor or expert, any advice given is strictly for the exploration of knowledge and making sure we share what we already know!"

Joined: Aug 26 2005
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oc coating

so is it the coating or the fillers that make the teva 80mg oxycotin extended release?...i.e. If I took the coating off and broke it in half would I recieve 40 mg of immediate release, of would the fillers still make it extended release?

Joined: Mar 21 2006
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Coating

Its the coating...! Without the coating you are right the OC would now be considered immediate release.

"I am not a medical doctor or expert, any advice given is strictly for the exploration of knowledge and making sure we share what we already know!"

Joined: Jun 18 2006
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ur wrong the time-release is

ur wrong the time-release is NOT in the coating.. the coating is merely paint.. the time-release is in the very composition of the pill.. if it is left whole, and intact, it will stay that way..

[post edited for content] 

Joined: Jul 25 2006
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coating....

  Yeah that makes sense 617 kid. I always thought it was the coating that made the pill time released but didnt understand how such a thin layer would let only some of the oxycodone out at certain times...

Joined: May 20 2006
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teva

ya I noticed the gel effect as well..bugged me out at first..but reading this really made for great info..

Joined: Jul 17 2006
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teva

TEVA's x*#&,  go with the OC's or the ABG's.

(edited by TeamPharmer)

Joined: Aug 3 2006
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Coating vs Composition for Time Release

Does anyone have specific references for this discussion?  If it's NOT the coating, then why are the manufacturers directions to NEVER break apart or chew the pill? 

I'm really not argueing, but I would love to read some specific references if some of you know where they would be.

Thanks

Karen M.

(edited by TeamPharmer)

Joined: Feb 15 2006
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Endo's generic oxycontin 

Endo's generic oxycontin  x*#&s!!!  Does anyone else have any problems with this version?   I have a script for them and  I have to use Wal-mart and they only carry the endo and won't or can't order anything else.  

 They do not last for 12 hours or even 8. It is more like 6 hours and when I take them I sometimes feel like I am having withdrawals.

Stomach aches, sweating and just an over all YUCK feeling.

The big one is that they don't control pain at all.  

I can't afford the name brand but now with medicare part D I might be able to. Well, that is if the pharmacy let's me fill my Rx with the name brand.

Joined: Mar 21 2006
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O.C.

Hello,

I have heard of instances where people getting Oxycontin prescriptions that didn't like a certain generic actually kept pleading his or here case to their doctor and eventually its possible the insurance will give in and fill a brand name or better suited generics for you. After all that is why there are different brands in the first place. I believe doctors can insist on a particular brand or generics also.

 

My comments are my opinions based on the questions posted on this message board and should be taken purely as is and not as medical gospal. Please consult medical concerns with medical proffesionals. Thank You!

Joined: Mar 20 2006
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they sure can... i am living

they sure can... i am living proof to this.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.
Joined: Dec 29 2006
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  i know this is sort of

 

 i know this is sort of an old thread, but i felt the need to chime in anyway. i would usually preface anything i say by telling you it's just my opinion, however, in this case what i'm about to say is fact, not opinion.

 the time release mechanism of oxycontin, ms-contin, and their generic equivilents has nothing to do with the coating. the coating is only used for color to allow easy and quick identification. however, the brand name 10mg OC's have no coating. they're just white.

the method of release is in the composition of the pill. it has to do with the way the molecules are bound. the rationale behind the crushing/chewing warning is that when it is crushed, that breaks the binds down in as similar fashion to when it desolves in your gut.  as for simply breaking it, the same thing can occour, but at a much smaller scale. breaking an 80 in half and swallowing it, you might get 12 or 15 mg instantly released as opposed to taking it whole. the difference, however, would be negligible.

 hope this helps.

av

 

 

i'm not a doctor, just a pain patient. keep that in mind when/if reading anything i may post.

Joined: Aug 22 2006
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Quote:breaking an 80 in half

Quote:
breaking an 80 in half and swallowing it, you might get 12 or 15 mg instantly released as opposed to taking it whole. the difference, however, would be negligible.

Isn't half of an 80 mg tablet 40? Are you saying that of the 40 milligrams (if the pill were distributed equally), only 10 or 15 milligrams would be released instantaneously? I don't see how that is possible. I'm not disagreeing, but am waiting for Phisher or Incognito to post something about this. No offense Kirby, but I know you don't usually respond to threads like this.  

Joined: Mar 20 2006
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this is a tough one. i dont

this is a tough one.

i dont think that we can really have an accurate informed answer since companies haven't put out any information on the misuse of this med. in other words the pharmaceutics of this type of experiment however popular in modern culture havent been scientifically explored to my knowledge.

in theory, i would think that as gtrplayer stated, if someone broke it in half then it would be 40. however as the OP stated if they had only broke it in half (not crushed it) then it very well might only give off that much OC.

i do agree that the time release is not in the coating but rather in the pills dynamics itself.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.
Joined: Aug 22 2006
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Same way with something like

Same way with something like Xanax XR? Granted, I'd never ever want that much XR in my body at one time, but would the mechanism be the same? I AM NOT ASKING BECAUSE I WANT TO ABUSE THE DRUG. I am asking because I am curious if the mechanism of action is the same.  Rawoody is probably able to answer this, he seems to have a lot of background in the science of these things.

Joined: Mar 20 2006
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i agree, Rawoody and/or

i agree, Rawoody and/or Incognito or even Mitomac (if he ever came around anymore) would be good to answer this.

i have very little insight on the sus release alprolazam.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.
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No Offense Taken!

No offense taken, gtrplayer. You're right. I don't respond in these threads because I'm basically ignorant of how most medicines work. Pharmaceutical science is not my 'thing' so to speak.Frown

But I will join this thread by saying that there is no way to determine how much oxycodone is dispersed if a tablet is crushed or broken.

Here is an excerpt from the OxyContin prescribing info (bolded in a boxed warning area at the top of the leaflet):

OxyContin TABLETS ARE TO BE SWALLOWED WHOLE AND ARE NOT TO BE BROKEN, CHEWED, OR CRUSHED. TAKING BROKEN, CHEWED, OR CRUSHED OxyContin TABLETS LEADS TO RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF OXYCODONE.

Link to OxyContin info

So we can't determine that if you break a tablet in half, only one half of the contents are released.

Edited by me to add the link to OxyContin prescribing info.


I'm not a pharmacist or a medical doctor. This message is not medical advice nor is it an offer to provide medical advice. All drug identifications should be validated by a licensed MD or pharmacist.
Joined: Aug 22 2006
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I don't want to know if the

I don't want to know if the Xanax XR is abusable, I'm simply questioning whether the "sustained release" mechanism in a benzodiazapine is the same as in opiate pain medications.  The leaflet that comes with Xanax XR says the same thing as the Oxycontin leaflets, "Do not crush, chew, or break this pill.  Swallow it whole". I've taken the same dose for 2 years now, and still have no idea why anyone would want to abuse a drug like Xanax or Xanax XR, as it leaves you feeling groggy sometimes when taken only as directed.  

Joined: Mar 21 2006
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It's good to see this

It's good to see this post in action once more Cool To be completely honest I really never knew for sure what was really behind the whole Sustained Release mechanisms, but my guess was that it was the coating and after much thought seemed be wrong because the pills composition sounded like a much more plausible answer. I found this link that might clear up things, or maybe it won't but there's only one way to find out.

"The rate at which a drug is released from a resinate is dependent on many factors. In many cases the rate is sufficiently slow that the resulting effect is an extended or sustained release over many hours. Further modification can be achieved by the use of coatings that restrict the release, or control the site of release."

The full link it found here ER & SR

or here

http://www.rohmhaas.com/ionexchange/Pharmaceuticals/release.htm

Please don't misunderstand me.. I'm not saying that this proves my statement but at the least I hope it sheds some light on the subject. In conclusion I believe that the extended release formulation is acheived by both specific pill compisition and special coating, again I must state that this is only my hypothesis.

The comments expressed by me on this forum are opinions and should not be percieved as recomendations or advice. Medical professionals are at best your main resource for anything medical.

Joined: Aug 22 2006
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Where did you find that link?

Where did you find that link? It's very informative, I just have never found something that detailed. Anyway, thanks for posting it. I'm going to read it later when I have more time. Looks interesting.

Joined: Mar 21 2006
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I know it's kind of

I know it's kind of a coincidence that I found the link, I really had no idea that there was a sort of definite answer. Now there is some article and research behind the idea that the coating has something to do with the extended release. 

The comments expressed by me on this forum are opinions and should not be perceived as recommendations or advice. Medical professionals are at best your main resource for anything medical.