Benzo comparison chart

7below's picture
Posts: 44
Joined: 2007-06-29

I've seen the opiate comparison chart. I thought I saw a benzo com,parioson chart on here once but I'm not sure. If I've missed it somewhere could someomr link me to it?

 

Regards





phisher's picture
Posts: 2218
Joined: 2006-03-20
check this chart.it is

check this chart.it is from

check this chart.

it is from the worlds leading authority of benzos

that link doesnt work, so i will just cut and paste the chart....

BENZODIAZEPINE EQUIVALENCE TABLE
(Benzodiazepine Equivalency Table)

Revised April 2007

This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP, Emeritus Professor of Clinical Psychopharmacology at the University of Newcastle upon Tyne, England. Sources: NRHA Drug Newsletter, April 1985 and Benzodiazepines: How they Work & How to Withdraw (The Ashton Manual), 2002. The approximate equivalent doses to 10mg diazepam (Valium) are given.

For a discussion of half-lives and equivalencies see also the Benzo FAQ document.

Benzodiazepines1Half-life (hrs)2
[active metabolite]
Approximately Equivalent
Oral dosages (mg)3
Market Aim4
Alprazolam
(Xanax, Xanor, Tafil)
6-120.5a
Bromazepam
(Lexotan, Lexomil)
10-205-6a
Chlordiazepoxide
(Librium)
5-30 [36-200]25a
Clobazam
(Frisium)5
12-6020a,e
Clonazepam
(Klonopin, Rivotril)5
18-500.5a,e
Clorazepate
(Tranxene)
[36-200]15a
Diazepam
(Valium)
20-100 [36-200]10a
Estazolam
(ProSom, Nuctalon)
10-24 1-2h
Flunitrazepam
(Rohypnol)
18-26 [36-200]1h
Flurazepam
(Dalmane)
[40-250]15-30h
Halazepam
(Paxipam)
[30-100]20a
Ketazolam
(Anxon)
30-100 [36-200]15-30a
Loprazolam
(Dormonoct)
6-121-2h
Lorazepam
(Ativan, Temesta, Tavor)
10-201a
Lormetazepam
(Noctamid)
10-121-2h
Medazepam
(Nobrium)
36-20010a
Nitrazepam
(Mogadon)
15-3810h
Nordazepam
(Nordaz, Calmday)
36-20010a
Oxazepam
(Serax, Serenid,
Serepax, Seresta)
4-1520a
Prazepam
(Centrax, Lysanxia)
[36-200]10-20a
Quazepam (Doral)25-10020h
Temazepam
(Restoril, Normison,
Euhypnos)
8-2220h
Triazolam
(Halcion)
20.5h
Non-benzodiazepines
with similar effects1, 6
Zaleplon
(Sonata)
220h
Zolpidem
(Ambien, Stilnoct, Stilnox)
220h
Zopiclone
(Zimovane, Imovane)
5-615h
Eszopiclone
(Lunesta)
6
(9 in elderly)
3h

  1. All these drugs are recommended for short-term use only (2-4 weeks maximum).

  2. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals.

  3. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience during switch-over to diazepam at start of withdrawal programs but may vary between individuals.

  4. Market Aim: Although all benzodiazepines have similar actions, they are usually marketed as anxiolytics (a), hypnotics (h) or anticonvulsants (e).

  5. In the UK clobazam (Frisium) and clonazepam (Rivotril) are licensed for use as anti-epileptics only.

  6. These drugs are chemically different from benzodiazepines but have the same effects on the body and act by the same mechanisms.


    all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.



gaucho's picture
Posts: 75
Joined: 2005-02-20
Benzo equivalence tables

Hi,

Simply go to www.benzo.org.uk and on the sidebar you will find a link to the table compiled by the world's leading benzo authority, Professor Dr.Heather Ashton, of Newcastle University.

One or two omissions may appear glaring, but the chances are that what you seek will be found there. Without this table I would never have known that both alprazolam and clonazepam, mg for mg, are each 20 times stronger than diazepam; 0,5mg of either is equivalent to 10mg diazepam.

Of course there are other factors which make such tables a little misleading. For instance, subjectively, one would find that 1mg of flunitrazepam had a much greater effect on the CNS than the standard 10mg diaz which these tables all seem to use. And nitrazepam is certainly a lot more effective as a sleeping agent in 5mg dosage than a 10mg diaz. But use them sensibly and you will learn and gain a lot from them. Tolerance is an issue not addressed. I suffer insomnia and must have different prescriptions each 7 days - for instance, this is a Rohypnol week, and next week will be a Mogadon week, etc. The only ones I refuse to contemplate are the 'Z' drugs, which have dreadful side-effects which are not made very clear by the manufacturers. Zolpidem (Stilnoct, Stilnox, and, in the USA, 'Ambien') is particularly bad with hallucinations, tachycardia, and next-day ataxia amongst them. A truly awful, dreadful drug which should perhaps have its licence withdrawn.

Gaucho

"NEVER ingest anything unless you are 100% sure what it is."




gaucho's picture
Posts: 75
Joined: 2005-02-20
same

Looks like somebody cut and pasted the chart before I finished writing my reply. Ah well, it will save you the bother of going to the site, though a very good and informative site it is!

Gaucho    PS Might have known who the interloper was! And while I'm at it, Phisher, what's wrong with your link? Works perfectly well so far as I can see...

 "NEVER ingest anything unless you are 100% sure what it is."




phisher's picture
Posts: 2218
Joined: 2006-03-20
gaucho

i wasnt sure if the link would work or not. sometimes in the past i have posted things that may work on my computer but then when i try to access it via another computer i find that the link isnt working properly.

i am glad in this case that it is working ok:)

and yes, i agree with you, the link is to a very good informative site for anyone who may be interested in learning about benzo's.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.



Eagles07's picture
Posts: 179
Joined: 2006-09-01
benzo's

I have a question.... the eqivulance charts ays that klonopin(clonazepam) is equal to xanex(alprazolam), yet sometimes I'll take 2 mg of xanex and then the next day take 4 mg of Kpin and it still seems like the xanex is stronger, do u know` why this? Sorry for the slooy hand writing, I had surger and my hand tiday.

(edited by TeamPharmer) 




phisher's picture
Posts: 2218
Joined: 2006-03-20
Eagles 07even though someone

Eagles 07

even though someone (you in this case) may take "equivalent" dosages it doesn't necessarily mean that it will fill equal; rather it simply means that the therapeutic effects should be similar.

i know that i have experienced the same thing that you mentioned (though with different drugs).

i guess it all goes back to the "different people react differently to different drugs".

additionally, the onset of action and the duration of action is very different for the two drugs that you mentioned.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.



Posts: 210
Joined: 2005-10-05
Does anyone know where

Does anyone know where Versed (midazolam) fits into this chart as far a benzo equivalence goes? I know its one of the stronger ones, usually only given IV/IM and usually for anesthesia IIRC.

PDX 




gaucho's picture
Posts: 75
Joined: 2005-02-20
Midazolam

MIDAZOLAM is most commonly encountered as tablets of 15mg strength; in Europe Galenika's FLORMIDAL and in many countries Roche's DORMICUM are the dominant brands. Roche also produce a half-strength version at 7.5mg. It is an extremely strong hypnotic benzodiazepine indicated for the relief of chronic insomnia.

I have yet to find an equivalence table which includes this drug, but personal experience makes me believe that it is a much stronger sleeping drug than temazepam, nitrazepam, flunitrazepam, in fact I would probably say it is the strongest sleep aid that I use in my rotations. Certainly i never take the tablet until I am actually tucked up in bed - it appears to me to be extremely fast-acting.

VERSED (sorry, don't know the manufacturer of that particular brand) is, I believe, an IV form of midazolam used almost exclusively in hospital settings ?as a pre-med before anaesthesia/operations.

"NEVER ingest anything unless you are 100% sure what it is."




gcdylan's picture
Posts: 411
Joined: 2007-05-03
gaucho excellent site (the

gaucho excellent site (the UK site) about benzo's Although I do not take the benzo's everyday I have decided to tell my doctor to cut them out of my monthly med's