Please help................Does anyone know the maximum doseage

Posts: 3
Joined: 2008-05-24

Does anyone know the maximum dosage for hydrocodone apap 10/500, my first dose an hour and a half ago has not eased the pain. My physicians office is closed and I am hurting.




Posts: 542
Joined: 2006-04-12
There is no maximum doseage

There is no set maximum doseage it depends on your tolerance and only a doctor can tell you have many you should be taking. I highly doubt that taking a second pill will do anything but provide more relief but i would ask a doctor



Posts: 9
Joined: 2008-05-21
Actually there is a limit of

Actually there is a limit of the APAP (tylenol) componentof 4000mg (4g) per day.  Thereafter, liver problems can ensue, hence, there are lower dosage hydrocodone formulation such as Norco 10/325, Xodol 10/300, then special prescription for compounding pharmacies that can specially formulate 15/80 for special cases.

If you are on 10/500, then do not consume more than 8 pills per day.  Request Norco from your doctor and express your concern for your liver and the tylenol content.  Xodol is not on generic and is expensive.  Compounding formulations are very expensive and most doctors do not write those scripts.  Special compounding pharmacies must be visited in order to obtain these specific formulations that are not mass produced by pharmaceutical companies. 

For long-term usage, 3000-3500mg of tylenol is recommended I have read if continued consistent usage of higher level tylenol is used.  Liver damage can occur from the tylenol. Without getting too deep into metabolism and enzymes, certain metabolic pathways can be inhibited, thereby leading to liver complications. 

Alternatives can be used, Vicoprofen (7.5/200mg of ibuprofen) or oxycodone (roxidone), morphine, dilaudid (hydromorphone), demerol (meperidine).  Though all except Vicoprofen are CII and more dependent on the extent of your condition.