METHADONE + KLONIPIN

DONEDOSER
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Posts: 39
 Joined: 2008-03-26

I was wondering if since methadone blocks receptors for opiate receptors, does it block benzo receptors or make it work weaker. Any knowledge would be great.

‹ Long term use of methadoneKlonopin Generic 1mg ›

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Submitted by DONEDOSER on May 28, 2008 - 8:12am. login or register to post comments

jpd93833
Posts: 154
 Joined: 2007-11-22
Nope

Nope methadone does not block out benzos. because there are two different receptors in your CNS for each of the drugs. Benzos in combination with the methadone actually makes the methadone more potent. regards, jpd.


May 28, 2008 - 8:47am login or register to post comments

hydro
Posts: 124
 Joined: 2008-04-22
don't over do it!

Try not to take more than prescribed of either one.  It can be deadly.  Where I live there have been many people die from methadone and benzo overdose in the past few years.  I even lost a couple of friends to it.  But I believe that methadone can work wonders if taken appropriately.


May 28, 2008 - 9:56am login or register to post comments

Director
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 Joined: 2007-05-22
Methadone and brain receptors

I have been on Methadone for five years for CP and as far as I know, Methadone does not block the brain receptors.  In other words, you can still take other medications for breakthrough pain that use the same receptors.  What the Methadone does do is block the euphoric or high you would normally might get from the drug.

I take Klonopin myself, along with Methadone.  I am prescribed 1 mg TID, and it works fine for me. 

 

 

 



May 28, 2008 - 3:10pm login or register to post comments

Eagles07
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Posts: 182
 Joined: 2006-09-01
jpd and hydro are correct

It does not block benzo's, it increases the potency of the methadone and is very dangerous.  I am off the methadone clinic now, but I too have seen people die from taking benzo's on top of their meth.  Truth is, that it's a bad idea to mix opiates and benzo's peroid.


May 29, 2008 - 2:14am login or register to post comments

DONEDOSER
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 Joined: 2008-03-26
I can not thank yall

I can not thank yall enough

-Chris 



May 29, 2008 - 9:48pm login or register to post comments

chemik
Posts: 64
 Joined: 2006-08-12
well, actually methadone

well, actually methadone doesn't block opiate receptors. it just has a strong affinity to them. i take methadone since many years now.

what makes methadone weaker (faster metabolism) are for example alcohol and phenobarbital.

then i think there are benzos that make methadone act longer, if they are metabolized by the cyp450 in the liver (most benzodiazepines), an exception should be lorazepam that is metabolized by another enzyme (simplified). anyway, all benzos and opioides / opiates act stronger when consumed at the same time.

(edited by admin) 



May 30, 2008 - 11:47am login or register to post comments