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I have been taking oxycodone for more than 2 years.  Last week my pharmacy was out of oxycodone and filled my perscription with Endocet.  From the very start I did not feel like I was getting the same pain relief.  I ended up sleeping at least 6 extra hours each day.  By the end of the week I was in severe pain and then proceeded to get flu like symptoms.  Today is the first day I have felt a bit better.  I spoke to my physician last week in the midst of the turmoil and he told me to tell the pharmacist they had to fill my perscription with oxycodone and not endocet.  In my particular case, Endocet is definitely not the same strength as oxycodone. 

I wanted to write this because I am sure this has to have happened to others in the past.  Let me know and Good Luck to all.

the symptoms you described as being flu like sounds like w/d symptoms to me. In no expert but from what I understand that appears to be the case. Hope you resolved your issue.

Sorry, but you are wrong. There are differences with generic brands. I also take Percocet for chronic pain. When my pharmacy switched to Endocet instead of the Watson brand I was used to taking, it not only did not work as well, but I also had an increase in side effects. I had to talk with my doctor AND pharmacist to figure out the problem. (had no thoughts at the time that it had ANYTHING to do with the med change). Turns out my pharmacist and doc had both heard of some people getting better relief with one generic brand versus another. I belong to a group for chronic pain and many members have experienced this as well.

This is taken from Wikipedia

"Bioequivalence is a term in pharmacokinetics used to assess the expected in vivo
biological equivalence of two proprietary preparations of a drug. If two products are said to be bioequivalent it means that they would be expected to be, for all intents and purposes, the same."

The "Regulatory Definition" for the United States is listed as: 

"The FDA considers two products bioequivalent if the 90% CI of the relative mean Cmax, AUC(0-t) and AUC(0-∞) of the test (e.g. generic formulation) to reference (e.g. innovator brand formulation) should be within 80.00% to 125.00% in the fasting state. Although there are a few exceptions, generally a bioequivalent comparison of Test to Reference formulations also requires administration after an appropriate meal at a specified time before taking the drug, a so-called "fed" or "food-effect" study. A food-effect study requires the same statistical evaluation as the fasting study, described above."

The 20% thing doesn't seem so far off now. I guess I won't have to call the FDA.

makes for good reading!

i always wondered where endocet came from. its percocet though, i got it at the pharmacy the other day and they told me its percocet.

I also find the watson brand oyxcodone 10/325 genrics to have more side efects than the endocet as well. I find an increase in nausea and also increased itching. Not sure why, but I too prefer the Endo's

PDX

 That may be true for alot of depressed people , but try telling that to someone that has chronic pain.

 Danielle Nelson

1ST OFF USING AN EXAMPLE OF SSRI vs. A SUGAR PILL-LET ME JUST SAY THIS MY NEUROPYCHIATRIST, HAS ME ON PROZAC.FOR TEN YEARS-WHEN THE GENERICS CAME OUT & THEY HAD THE CHANCE FOR PATIENT FEEDBACK, MY TRUSTED DOCTOR HAS RECIEVED MANY COMPLAINTS IN REFERANCE TO ALL THE GENERICS OF PROZAC WITH THE EXCEPTION OF DISTA (WHICH IS A SISTER CO. OF LILLY, THE ORIGINAL MAKERS). I TOLD HIM A LONG TIME AGO I FELT I WAS SPINNING MY TIRES AS WELL AS NOT BEING ABLE TO KEEP DEPRESSION BOUTS AT BAY. HE ASKED ME IF I WAS GETTING THE GENERIC- YES I WAS, SO HE IMMEDIATELY CHANGE ME OVER TO THE NAME BRAND. I HAVE HEARD SOME EXTREMELY UNFORTUNATE CIRCUMSTANCES OF PEOPLE I KNOW THAT STILL HAVE SEVERE DEPRESSION & CAN'T SEEM TO GET A HOLD ON IT.THEIR INS. IS NOT CONDUSIVE TO NAME BRANDS AND THEY CAN'T AFFORD THE $$$$$.THESE ARE WELL ADJUSTED PEOPLE WHO WORK HARD AT BEATING THE DEPRESSION.A CASE I HEARD OF WHICH IS TERRIBLY HORRIFIC, IS OF A MAN WHO WAS SUNK IN DEPRESSION (TAKING THE GENERIC PROZAC)JUST FELL PREY TO THIS MONSTER, THE ILLNESS TOOK HIS LIFE FOR HE GOT SO BAD, HE HUNG HIMSELF. THIS WAS A FRIEND OF MINE- who found his lost friend) HIS ROOMATE & BEST FRIEND FOR OVER 30 YEARS.-AS FOR PAIN GENERICS THERE ARE DIFFERANCES MY DEAR PHARMACIST, YOU ARE NOT IN ANY POSITION IN ALL HONESTY TO PASS IT ON AS TO BEING IN ONE'S HEAD -YEAH I KNOW YOU SEE THIS EVERYDAY. DO YOU PHYSICALLY EXPERIANCE DEBILATING PAIN? HAVE A CHRONIC IRREVERSABLE ILLNESS, THAT CAN NOT BE SURGICALLY CORRECTED?I DO. EVERY PERSON IS JUST THAT A PERSON ,UNIQUE, AS THEIR OWN FINGERPRINTS.BODY AND BRAIN CHEMISTRY ARE HUGE FACTORS. A PERSON WHO KNOWS REAL PAIN AS I AM SURE MANY OF US ON THIS SITE,KNOWS THE TIMING, REACTION, AND PROBLEMS DIFFERENT PAIN MEDS OVER LONG TERM USE CAN CREATE-TOLERANCE LEVELS, MANY THINGS.I AM TAKING MALLINKRODT 10/325'S I KNOW IT IS NOT THAT GOOD OF A GENERIC, I HAVE TRIED WATSON-NORCO THAT GAVE ME DRY HEAVES & I GUESS THAT WAS ALL IN MY HEAD AS WELL. I KNOW I NEED TO DISCUSS THIS WITH MY DR.A PHYSIATRIST, HARVARD & JOHN HOPKINS & CLEVELAND CLINIC- AND A FOUNDER OF CHICAGO INSTITUTE OF NEUROSURGERY & NEUROSCIENCE.AND AN AUTHOR OF SOME EXCELLENT BOOKS.FACING PAIN /FINDING HOPE.I AM BLESSED HE IS CARING FOR ME.THERE ARE DIFFERANCES IN GENERICS /NAME BRANDS.IT IS NOT IN MY HEAD-NOR DO I THINK OTHER PEOPLE THAT ARE INVOLVED IN THIS WONDERFUL, INFORMATIVE SITE. I HAVE LEARNED MUCH AND APPRECIATE ALL COMMENTS EVEN YOURS.WE ALL HAVE OUR OPINIONS -I CAN ONLY SHARE MY EXPERIANCE, STRENGTH AND HOPE. THANKS

As the original poster of this thread, I find a few interesting responses. Yes its true that all generics must meet similar guidelines but there is different filler material that is used that may be what causes different reactions. As far as hydro/apap 10/325 tablets go, kind of like with Percocet and endocet, watson makes both the brand name (Norco [Norco 529]) and a generic (watson 853) that look almost identical except for the imprints. I have never tried tyco-mallinkrodt 10/325's but I know I was unimpressed with their 10/500s. I have tried qualitest and they feel just as effective as the watson-Norco variety. I also know that the majority of generics for benzodiazepines are just as effective as the brand except for maybe xanax which is a newer one and I've heard the brand name on that is way more potent. Just some thoughts. Wow, this turned into a popular thread after getting few responses for a relatively long time.

Take care all

JeckPDX