Opioid Comparison

Posts: 640
Joined: 2005-07-25

I've seen a couple of people ask about comparison of one opioid against another and came up with a sample list. I didn't want to lose it and wanted it shared so hopefully this will be a good place as a repository. If there are any mistakes or additions please feel free to add.

This is just a quick comparison so no quoting, as it is only single sourced. Also amounts shown are only for comparison in relation to each other.

Opioid Conversion Table

Opioid Strength (Codeine) Equivalent Dose (30 mg codeine) Strength (Morphine) Equivalent Dose (10 mg morphine mg)
Aspirin 1/36 1080 mg 1/360 3600 mg
Difusinal 1/16 480 mg 1/160 1600 mg
Dextropropoxyphene 1/4 120 mg 1/40 400 mg
Codeine 1 30 mg 1/10 100 mg
Tramadol 1 30 mg 1/10 100 mg
Anileridine 2.5 12 mg 1/4 40 mg
Demerol 3.6 8.3 mg .36 27.8 mg
Hydrocodone 6 5 mg .6 16.67 mg
Morphine 10 3 mg 1 10 mg
Oxycodone 15-20 1.5-2 mg 1.5-2 4.5-6 mg
Morphine IV/IM 40 .75 mg 4 2.5 mg
Hydromorphone 50 .6 mg 5 2 mg
Oxymorphone 70 0.4 mg 7 1.4 mg
Levorphanol 80 0.26 mg 8 .8 mg
Buprenophine 400 0.075 mg 40 .25 mg
Fentanyl 500-1000 0.03-0.06 mg 50-100 0.1-0.2 mg
Carfentanyl*** 1,000,000 30 pcg 100,000 100 pcg

***Used only in sedating large animals.

Sources:

Palliative.org

opioids.com

University of Illinois

SpineUniverse

Wikipedia - Tramadol

Wikipedia - Morphine

Wikipedia - Oxymorphone

Wikipedia - Carfentanil

redpoll.pharmacy.ualberta.ca

www.dea.gov

designer-drugs.com





phisher's picture
Posts: 2217
Joined: 2006-03-20
nice Rawoody! that is a very

nice Rawoody! that is a very good list and looks pretty accurate. i know it is hard to put togethter a list since they are all slightly different. i understand that it is equal doses but is this one for someone who is opiate niave or tolereant?





Posts: 1240
Joined: 2005-05-16
He says they are in

 

He says they are in comparison to each other, so I would 'guess' that this list is only (semi-)accurate in a person who is naive.

It does however give comparisons that might be useful to anyone.  




phisher's picture
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where does dihydrocodiene

where does dihydrocodiene fit in? i have always had a hard time finding its strentgh to ratio.

i know on rx indications it often states "for moderate to severe or moderate severe pain"

 





Posts: 640
Joined: 2005-07-25
Dihydrocodeine

Same potency as codeine.

Source:

http://en.wikipedia.org/wiki/Dihydrocodeine

 

Also as an example to make sure things are clear:

Hydrocodone65 mg.616.67 mg

Using hydrocodone as an example, the 6 refers to the potency as compared to codeine. The second number refers to how much hydrocodone is needed to be equivalent to 30 mg of codeine.  THe 3rd number(.6) and the 4th is the same as the first 2 but in relation to 10 mg of morphine.




Posts: 1074
Joined: 2005-01-07
Opioid Comparison

Thanks for the post, Rawoody. Your information is very interesting and will help readers wanting to compare the relative strengths of various opioids.

We put an excerpt of your post on the front page.



phisher's picture
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Joined: 2006-03-20
one last question. do you

one last question. do you have any idea where levorphanol into the chart. i have had a difficult time researching this medicine. i understand that it is an inexpensive medicine and from the best i can tell it is a morphine dirivitive but i have also read things saying that it was similar to methadone. needless to say i am very confused. any help is appreciated.





Posts: 640
Joined: 2005-07-25
Nope... not yet.... will try

Nope... not yet.... will try and if I do.. I'll post it.



Posts: 2
Joined: 2006-06-28
would Carfentanyl be the

would Carfentanyl be the same as ketamine? or is that a totally different thing



Posts: 157
Joined: 2006-04-24
Carfentanyl vs. ketamine

Carfentanyl is completely different from ketamine.  While ketamine is widely used on animals as well, it is also used in humans for anaesthesia and even treating migraines.  Carfentanyl, on the other hand, is way too potent to be considered for human use, therefore is only used in veterinary practice to sedate large animals. 



Posts: 640
Joined: 2005-07-25
Phisher

Levorphanol is listed as 8x as potent as morphine.

Source:

http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00764.txt

Anileridine = 2.5x Meperidine and .25x morphine

Source:

http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/anileridine.html

Dextropropoxyphene (Darvon) .25-.33x codeine and approx 9x ASA

Source:

http://www.dea.gov/pubs/abuse/4-narc.htm 

Buprenophine is approx 40x Morphine

Source:

http://www.dea.gov/pubs/abuse/4-narc.htm 




phisher's picture
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Joined: 2006-03-20
outstanding work as usual

outstanding work as usual rawoody, thanks alot! i have had a time trying to find any good info on the med. it is odd b/c not alot of people seem to be rx'ed to it yet it is so cheap. for one reason or another doctors dont choose it often and i was just curious its potency in relation to other drugs in that class.





Posts: 640
Joined: 2005-07-25
Bump

I've asked David to update the chart to reflect the most recent additions... note that I added aspirin to show much stronger opoids are in comparison (Thought it might be useful.)



Posts: 640
Joined: 2005-07-25
Pentazocine

Pentazocine (Talwin) is considered to be 1/3 to 1/6 (ave. 1/4) as potent as morphine.

 

Source:

http://arthritis.about.com/od/talwinnx/




phisher's picture
Posts: 2217
Joined: 2006-03-20
i thought this was

i thought this was interesting

http://www.oqp.med.va.gov/cpg/cot/G/OT_Med.pdf

though i still think that rawoodys is more representative of the majority of the tables i have seen.

also his is much more comprehensive but nevertheless it is interesting.


all thoughts and opinions expressed are those of my own and should not be mistaken for medical advice. i am not a doctor nor a pharmacist. all medical questions should be answered by a licensed pharmacist, doctor, or primary care manager.



Posts: 1240
Joined: 2005-05-16
               

                            ^=bump=^

Keeping this close to the top (or atleast on the first page) will probably help answer many questions. And keep it from getting buried.




Posts: 640
Joined: 2005-07-25
Bump

Bump




Posts: 1074
Joined: 2005-01-07
Bump

We added a permanent link to the menu item Health, Drug Topics.

Rawoody's chart is in the subsection All You've Ever Wanted to Know About ....

Would a 'sticky' post at the top of this forum (Discussion of Prescription and OTC Meds) be better?




Posts: 1240
Joined: 2005-05-16
I think a 'sticky' would

 

I think a 'sticky' would benefit many users. Between the link in the 'Health, Drug Topics' and a sticky post, this thread would be hard to miss.

I believe that some users never venture into the 'Health, Drug Topics' menu.

It would also benefit those looking for this info, but do not use the search feature for whatever reason. And more often those searching for this info, but do not necessarily know the proper search terms they are looking for or need to use.




miltonpaige's picture
Posts: 23
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what about morphine or fentanyl

can i ask a?

how many 30mg codeine would be = to 20mg hydrocodone 

 

<<<,,,<,HaV0K..>>..>..>p3aCe...ONE LUV.




gtrplayer's picture
Posts: 2609
Joined: 2006-08-22
Sorry, you're going to have

Sorry, you're going to have to do the math on the other two.

Here is a screen shot from Globalrph.com

 

Narcotic analgesic converter
This document Copyright © GlobalRPh Inc, All Rights Reserved

Read the disclaimer
Converting from
Step 1: Select a narcotic analgesic to convert Codeine IM/SC Codeine (oral) Fentanyl IM/IV Hydrocodone (oral) Hydromorphone (IM) Hydromorphone (oral) Meperidine (IM/SC) Meperidine (Oral) Methadone (IM/SC) Methadone (Oral) Acute Methadone (Oral) Chronic Morphine (IM/SC) Morphine (Oral) Oxycodone (Oral) Oxymorphone (Oral) Oxymorphone (IV/IM)
Step 2: Enter total daily dose: mg
Reduction for incomplete cross tolerance: %
(Usual range: 25 - 75% reduction)
Converting to
Step 3: Select a narcotic analgesic to convert Codeine IM/SC Codeine (oral) Fentanyl IM/IV Hydrocodone (oral) Hydromorphone (IM) Hydromorphone (oral) Meperidine (IM/SC) Meperidine (Oral) Methadone (IM/SC) Methadone (Oral) Acute Methadone (Oral) Chronic Morphine (IM/SC) Morphine (Oral) Oxycodone (Oral) Oxymorphone (Oral) Oxymorphone (IV/IM)

 
Based on your selections above, here is the result:
Equivalent dose for opiate selected in Step 3 above: 4.50 mg
Reduction for incomplete cross tolerance: 0 %

Gtrplayer




Posts: 1
Joined: 2007-06-10
Accuracy of Demerol Strength

i've done a little bit of reaseach and i'm finding that your demerol strengh might be off. please correct me if i'm wrong

http://www.uofapain.med.ualberta.ca/images/UGPainlecture1dec2006.jpg

http://www.uofapain.med.ualberta.ca/opioidconversion.htm

 

btw, this is a really nice site

 

[EDIT]

oh, i see where the conversion came from, you were using IV rather than oran Demerol.

It seems that you switch between oral and IV/IM for your morphine comparisons. 




brodank's picture
Posts: 38
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thanks, that has already

thanks, that has already been a big help!



thatswhatsup's picture
Posts: 259
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what about methadone acute and chronic?

what about methadone acute and chronic? 

*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*




gtrplayer's picture
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When is methadone used in an

When is methadone used in an acute setting?

I'm assuming the "acute" part means "IV"

 




brodank's picture
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Joined: 2007-06-25
i am still havin problems

i am still havin problems convertin this (guess i shoulda payed more attention in math class)like how many mg's of codiene would i have to take to equal like 1-10 mg lortab.......



thatswhatsup's picture
Posts: 259
Joined: 2006-07-17
It's a wonder you got out of

It's a wonder you got out of preschool if can't multiply 6x10=60mg of codiene.  ok 4th grade but still....... 

*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*




brodank's picture
Posts: 38
Joined: 2007-06-25
WOW

wow thanks, that BS in psychology is really payin off huh!



thatswhatsup's picture
Posts: 259
Joined: 2006-07-17
definately not

IV means intraveinously.  acute is for short time period, chronic is for long term use since the half life builds rapidly, personally I know where it fits in the chart but its just not in it and sometimes it varies so much from person to person that they might just have not wanted to mess with it. 

*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*




gtrplayer's picture
Posts: 2609
Joined: 2006-08-22
I know.

I know.

But Methadone is not to be a first line analgesic. We've all read about the kid with tooth pain, and the dentist gave him Methadone. I'm not saying it doesn't happen, I'm just saying that it's not a conventional form of acute medicine.

 




thatswhatsup's picture
Posts: 259
Joined: 2006-07-17
i didnt hear that one but I

i didnt hear that one but I think it means when you first switch from a less potent narcotic and don't have methadone built up in your system, so when you first start on it you don't have days and days of half-lifes of the drug left in your system like you do once you start a daily regimon for a long period. 

*None of this should be construed as medical advice. You should always speak with a licensed MD. or medical professional for professional medical advice. These opinions are my own and should not be taken as professional medical advice*




slitter028's picture
Posts: 290
Joined: 2008-02-09
Reckless methadone prescribing

 I went to my FAMILY DOC of like 25 years complaining about migraing headaches....and outta the blue he writes this script for methadone....LOL, I was floored, it workedSealed..still to this day he hasn't done it again, although i haven't seen him  in years, he dropped me as a patient when he found out I was HIV+and the was in 1999 (YES, it still happens, this is rural ky)......Ray

 Remember: Just do it.. EVERY PILL  EVERY DAY




Posts: 3
Joined: 2007-07-02
Methadone

Methadone is used for both actually but the reason why drs use it with chronic pain is because it has a half -life of half.lol. Take 50mg at 8am monday and 8am tuesday there are still 25mg in your body and also it builds and builds this is why alot of ppl take it and say well it dont work but its stronger than hydro and I do think that it is stronger than hydromorphone.



brodank's picture
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Oxycodone

why is Oxycodone 15-20 ......why does it vary???



gtrplayer's picture
Posts: 2609
Joined: 2006-08-22
because of conflicting

because of conflicting information.  Some places have oxycodone as 2.0 X as strong as hydrocodone, while others have it at 1.5 X as strong as hydrocodone.   




Posts: 9
Joined: 2007-06-14
good info,thanks

good info,thanks



slitter028's picture
Posts: 290
Joined: 2008-02-09
tolerance and response

It all depends on other drugs you're taking, your particular response to the drug, the effects of the other drugs on the narcotics, and just how they affect you and how you metabolize them...something i might take might put someone else underground....It's subjective as a function of tolerance.

Ray

Remember: Just do it.. EVERY PILL  EVERY DAY




KnightMetal's picture
Posts: 470
Joined: 2006-06-05
awesome, like that chart!

 

 

1 question, or where is the Methadone (dolophine)? As it is still can be prescribed 4 pain as well. Several of my sources say that

Levomethadyl Acetate ,Buprenorphine & Methadone as different drugs.

KnightMetal

  • I am not an MD
  • I know by experience only
  • Please do not take advise from anyone, consult YOUR MD 1st

(DONT GET ME WRONG, I AM NOT COMPLAINING, I LOVE THIS CHART, I JUST WANT TO KNOW WHERE THEY STAND IN THERE)




Posts: 1
Joined: 2007-11-08
Well this blog is a real

Well this blog is a real encyclopedia concerning drugs. I had a lot to learn here, these informations are very useful specially if we think about people fighting addiction.

Edited by Mod3 - please, no links to commercial enterprises except:

  • Pharmaceutical manufacturers
  • Pharmaceutical websites like Requip, Chantix etc.
  • Websites for consumer drug information, pill images, pill identifiers - for example Drugs.com, Holy Family Memorial Hospital, RXList.com
  • Other sites supplying free pharmaceutical and medical information that are approved by us

 




Posts: 3
Joined: 2007-11-18
Very informative drug

Very informative drug comparison chart.

(edited) 




Posts: 1
Joined: 2007-11-26
drugs

this is a very good list very good comparison.
 
Edited by Mod2 



Posts: 1
Joined: 2008-02-18
Morphine

So morphine ain't that strong anyway. Maybe it isn't that good you've made this comparison.. people could use it in bad purposes.

 

_____________

 




solo5010's picture
Posts: 1089
Joined: 2005-10-06
 People can use spoons for

 People can use spoons for bad purposes too, but I still like to eat ice cream with them. What do you mean by "morphine aint that strong anyway"? 



slitter028's picture
Posts: 290
Joined: 2008-02-09
Real life Opioid Comparison

..It's funny, because I had a colonoscopy done last Monday, I know you didn't want to know that, just as much as i didn't' want to have it, but they gave me 20mg versed and 500mcg of fentanyl and I don't feel like it affected me as much as it should have and compared to all the other people i saw everyone was zonked and i was WIDE awake, and it kinda scares me ...and it's also weird that i've not taken either of those drugs extensively, versed once or twice and that was the first time for fentanyl, don't get me wrong, i didn't feel any pain or discomfort during the procedure, but I makes me wonder about anesthesia awareness...God, would that be HORRIBLE!!!

Ray

Remember: Just do it.. EVERY PILL EVERY DAY

(edited) 




Posts: 10
Joined: 2007-11-08
Yeah, since you're not what

Yeah, since you're not what they call "opiate naive" they affected you less.  Your receptors need a certain amount of any opiate (tolerance), so that's why you were probably far and away the least affected.

If there is a next time, let them know that you aren't sedated easily, they'll adjust the dosage.  If worse comes to worse, act like you're panicking and don't feel anything.  haha.

Edit: Wow, I just noticed this was a few months old.  Apologies.