oxycodone vs. hydrocodone

Posts: 9
Joined: 2007-02-02

Hello everyone,

I was in a discussion with my nursing colleges about the difference in strength between oxycodone (Tylox) and hydrocodone (Lortab) . I have seen Md's prescribe both for pain management after surgeries or injuries, but what I have witnessed is that the doctors would prescribe more hydrocodone than oxycodone per dosing time. meaning take two Lortabs (5mg) every six hours compared to taking one oxycodone(5mg). I believe there is not much difference, maybe just a little strong on the tylox side, but not much. What do you guys thimk.

Have a blessed day, Thanks

pbhgx3




gtrplayer's picture
Posts: 2636
Joined: 2006-08-22
According to Globalrph.com,

According to Globalrph.com, 7.5mg of hydrocodone is equivalent to 5.0 mg of oxycodone.  So, it makes sense, to me anyhow, that doctors might write to take 1 or 2 tablets of hydrocodone, and only 1 tablet of oxycodone.  But, everyone is a little bit different, so what works for some might not work for others.  

Gtrplayer 




Posts: 659
Joined: 2007-01-31
Yeah, that's what I have



Yeah, that's what I have found on here: oxycodone is about 1.5x the strength of hydrocodone. plus, there is oxycodone IR and ER. I think sometimes in mind doctors may associate percocet (IR) with oxycontin (ER). they think one may lead to another, or they are in the same class, so if possible, they may try to stray away from the immediate relief oxycodone to something that doesn't have as strong ties to something else. does this just sound like a mess, or is it understandable?

 

I'm a social worker, not a medical professional. All comments and thoughts are simply my opinion and experience.




Posts: 4
Joined: 2007-05-22
I think that 5mgs of any pain medication is not helping....

I just read your comment on oxycodone versus hydrocodone and I just wanted to comment on this subject. I do not feel like 5 mgs of either one is any good for nothing unless it is a sprained ankle. I am not trying to sound rude at all. I take 10 mg hydrocodone 3 times a day and it helps alot. I can not imagine my doctor even starting me out on 5mgs of it. Either one. I have taken both. No I am not a doctor or studying medicine in any way. But in my defense, I do think 5 mgs is a great dose for small or younger people to start out on. But as far as surgeries go, and I am only 22 and have 2, 5 mgs of either one would not be enough for anything about pain control. I was given 30 10 mg hydrocodone and Tylox every week until I was better. I currently get the hydrocodone prescribed for a reason. As for going in surgery I hope doctors out there no how to handle pain better than 5 mgs of anything. Doctors have told me Ultrams are the best pain meds. I had to laugh to myself. That is truly unbelievable that any doctor who has a degree in treating pain, and yes I am talking about ER doctors to, would give you Ultrams for something that is really bothering you, unless of course they are dumb to the fact that it does nothing for most people. I think doctors and nurses now do not want to give out real pain medication because of all the hype about the big addiction part of it and that makes it worse for the people who really do need the medicine. If I wanted 800mg Ibuprofen or Naproxen I would go to my local drug store and pick it up. That is truly laughable.



Posts: 2
Joined: 2007-11-14
5mg doses

I agree with you.  Doctors are so paranoid that they'll be criticized for giving out unnecessary pain medication that they treat Vicodin 5/500s like they were gold or something.  It didn't used to be that way but in the past 6 or 7 years it seems that everyone is ultra conscious about the abuse of pain medication to the point of absurdity. 

Vivationman




Posts: 944
Joined: 2007-04-12
Pain is an entirely

Pain is an entirely subjective experience.  The same injury or proceedure can be percieved as painless by one person and terribly painful by another.  One person will get complete pain relief with Ultram, and another will get no pain relief with anything.  Most c/section patients (when I was a resident, back in the day) were discharged on the third day post-op with motrin alone, and did not need anything else!  Ultram is a great drug for a number of patients I see.  I had a patient who was on 40 mg OxyContin three times a day, when he broke a tooth.  He called in terrible pain.  His dentist couldn't see him until Monday.  I told him take Motrin.  He was astounded by the way over the counter motrin worked so much better than 40 mg of OxyContin.




Posts: 746
Joined: 2007-06-28
And one must consider the

And one must consider the cause of pain. 

A typical sinus headache is better treated with anti-infammatory like ibuprofen than with oxycodone alone.

MANY people that suffered for years with pain and tried large doses of all many of concoctions finally found relief with simple gabapentin. 

Opiates or similar medications are not always the best choice.




Posts: 1
Joined: 2007-05-23
Vicodin/Oxycodone(percocet)

I'm allergic to vicodin, and when I had a tooth pulled they wouldn't give me oxycodone(percocet), the dentist said it's way stronger than vicodin. He might have been just saying that because I asked for it. The only reason I did was because I had it before and knew I wasn't going to have a swollen tongue and hives. I don't really like oxycodone, (5mg generic for percocet) the ER doctor prescribed it when I had an abscess tooth, makes me nauseous, better than pain though if you lie down.

I just read your comment and when I had a cesarean, the doctor messed up and prescribed me vicodin, he had already left the hospital when I found out. He then went home and didn't want to bother coming back, and he can't call narcotics in to the pharmacy, apparently it's illegal here, so he called Ultram in. Completely worthless. I took it and I was still in so much pain I couldn't walk. I ended up having to drive 30minutes to get a prescription from him the next day.




Posts: 41
Joined: 2007-05-17
It is illegal to phone-in

It is illegal to phone-in oxycodone-containing products, like percoset or percodan, or to allow refills on them because they are a higher schedule class of a drug.  Yoou can phone-in hydrocodone-products, like vicodin and vicoprofen in, though b/c they are not scheduled as high by the FDA.  As for Ultram, it might as well an OTC drug.  It is a joke.  You would have to eat the whole bottle to get any pain-relief.  I seriously don't understand why it even exists.



Posts: 19
Joined: 2007-05-02
weak

Yes I to think 5mgs are pretty much good for nuthin unless you take more than one at a time, thats hydros im talkin abt, but the 10 mg, and the 7.5 vicoprofin, and norcos are rite on time. I dont understand why the doctors around here dont prescribe the 7.5 vicoprofins more, unless more people are allergic to ibuprofin maybe? I think my opinion the 7.5 / 200 vicoprofins are even better than the 10mg generic hydro/ tylenol. As far as the ultrams, i have never tried them but it sounds in my opinoin similar to darvocet, or ultracet which are good for a headache but thats abt it. I cant figure out why there a schedule 3 narcotic. Thats funny to me.



Posts: 659
Joined: 2007-01-31
I guess it is true that it

I guess it is true that it depends on your physical makeup as well as other factors, myself the 5mg used to work- years ago, when i was first getting them- but then again, I am smaller. A 190lb man, who never really took pain meds at all before, took the same 5mg and it did NOTHING. he had to take 2 5mg tabs, and it barely relieved the pain.

I think the reason vicoprofin is not prescribed as much is because ibuprofen eats at your stomach lining whereas tylenol messes with your liver- it's like which is the lesser of the two evils? actually, tylenol is b/c the liver can recover either better or faster than the stomach lining. more often, you will see dentists prescribe vicoprofin b/c they say the ibuprofen works better for dental pain than tylenol does. however, this is supposed to only be for a short-term use.

back in the day, before pain meds were abused so much, ultram probably was significant for something, now there are more bigger and better meds, leaving the ultram (tramadol) almost obselete. 

I'm a social worker, not a medical professional. All comments and thoughts are simply my opinion and experience.




quahog's picture
Posts: 279
Joined: 2006-02-15
Actually this varies from

Actually this varies from state to state. Some states allow CII meds such as Oxycodone to be called in for emergency situations. However, they usually only allow a few days worth.



gcdylan's picture
Posts: 398
Joined: 2007-05-03
Actually in some states you

Actually in some states you can call in Sch 2 med's if the doctor get's it to the pharmacy in a certain amount of hours In wyoming I think it is 72 hrs,but I know in Wy Sch 2's can be called in



Posts: 1
Joined: 2008-05-13
Oxycodone

You see oxycodone is stronger and more addictive than hydrocodone, the are both schedule II drugs but oxy is still more powerful. You can call a pharmacy ordering hydrocodone but you cannot call in oxy. Some people say that there is a difference but I have tried both and oxy is 10x stronger.




Posts: 544
Joined: 2006-04-12
Oxycodone is schedule II

Oxycodone is schedule II however hydrocodone is only Schedule II when it is in a compound with less than 80mg acetametaphin or more than 15mg of hydrocodone. All mass produced hydrocodone tablets are schedule III not II. The only way to get Schedule II hydrocodone is from a compounding pharmacy where they make the specific formula for you and put it in a capsule. Oxycodone is said to be 1.5-2 times stronger than hydrocodone.



Posts: 1
Joined: 2008-05-30
Oxycodone is so much better

In my opinion Oxycodone is 10x better as pain relief than hydrocodone.  Vicodin is a schedule 4 whereas Perc is a 2 (way stronger).  but is very much more addictive. 

But i agree that it sucks for those of us that need the medicine that there are so many abusers out there, bc dr's are much more hesitant to prescribe them.  I hate that.  But yes, Oxy is waaaaaaay better.  And as for the nautiousness noted, that part goes away after your 2nd or 3rd dose.

EMSmel (emt, phar. tech)

 




kirby's picture
Posts: 3544
Joined: 2004-12-26
Oxycodone/Hydrocodone

Hi EMSmel (emt, phar. tech),

I'm kirby (BS in Accounting, CPA).

I like numbers so I want to correct one of your statements.

Vicodin and generics are Schedule 3 - not 4.


I'm not a pharmacist or a medical doctor. This message is not medical advice nor is it an offer to provide medical advice. All drug identifications should be validated by a licensed MD or pharmacist.



Posts: 8
Joined: 2008-06-06
Ok everybody - here's the

Ok everybody - here's the difference between oxy being a schedule 2 opiate, and hydro being a schedule 3 - hydrocodone (vicodin, lortab, norco, etc.) can be prescribed in doses ONLY up to 10 mg per dose. Oxycodone can be prescribed for anything from 5 mg, all the way up to 80 mg, per dose. This makes oxycodone a schedule 2 substance. The same cannot be said about hydrocodone. Once you get up to 10 mg, that's it. Can't go any higher than that - thus the lower DEA drug scheduling given to oxycodone products (percocet, oxycontin). There is no time-release for hydrocodone-based medicines. I WOULD know about this, because I am a person with a brain disease (I won't say what it is...), and I have been on percocet (oxycodone) based products for almost a year now, due to horrible migraines that I experience daily. There is no real definitive difference between the two drugs, except for DEA scheduling. I have taken both of these in my lifetime, and I have to say - I can't really tell, or feel, a difference between oxy and hydro. I am currently taking oxycontin 20mg extended release, once every twelve hours, because I have all these stupid migraines. Hope this helps with any confusion that everybody may be having. ALSO - I've read about how a LOT of people don't seem to be helped by 5mg ANYTHING...

Best of luck to all who are suffering from chronic pain and disease. God Bless. -drewfuss

(edited) 




Posts: 544
Joined: 2006-04-12
Actually a doctor can

Actually a doctor can prescribe hydrocodone in any dose it just has to be compounded. The highest mass produced hydrocodone compound has 10mg but if it is below 15mg and at least 80mg tylenol it is still schedule III. The scheduling has nothing to do with the amount in the pill because a 5mg percocet is still in schedule II when a 10mg lortab(technically stronger) is still only schedule III. It has to do with abuse potential and oxycodone is 1.5 times stronger. Also you say there is no extended release hydrocodone when Tussionex which is a liquid contains a hydrocodone polystyrex iirc and is an extended release formula although it is a liquid not a pill. And there is a difference between oxy and hydro codone.....oxycodone is 1.5 times stronger so saying there is no difference except for scheduling is completely false. Although they are both semi-synthetic opiates they are different chemicals and different strengths per mg so saying there is no difference is false, dangerous, and misleading information.



Posts: 8
Joined: 2008-06-06
Ok, I'm not TRYING to give

Ok, I'm not TRYING to give false, or misleading info, but you're right - both are synthetic opiates, and both have ALMOST the same chemical makeup and composition; with the difference being a few different molecular chains in the elements/chemicals/what have you...  all I know, is that once I forgot to bring my percocet/oxycontin to my girlfriend's apartment one night, and she had some leftover Tussen-X...  I took a few tablespoons of that for my migraine, and that, being hydrocodone based, did pretty-much the same thing for my migraine pain, as oxycodone does.  There is little difference between the two, until you break it down into molecular compounds - and how many people here are chemists?  That's what I thought.  Not much difference here, either one works, except for the fact that a doctor cannot just "call in" oxycodone, rather they ARE able to call in hydrocodone, because of its scheduling by the DEA.  And once again, that is due to the strength of hydrocodone (5mg, 7.5mg, and 10mg).  Oxycodone comes in anything from 5mg, to 10mg, to 20mg, up to 80mg.  So THAT is the reason why it is schedule 2 on the DEA drug list, versus hydrocodone being a schdule 3 substance on the DEA's drug list.  Again, not trying to mislead or misinform anybody, and I am NOT a physician, BUT - I recently, a few months ago, had my neurologist take me off of "Fentanyl" 75mcg patches, because the morphine-based meds keep ME (not necessarily others; everybody is different...) from being able to urinate properly, along with this stupid brain disease I have.  I told her that codeine-based meds (such as lortab, percocet, tylenol3) DON'T hinder my ability to urinate; so she got her little medication booklet out, and WHAM - she actually did find out that oxycodone is a codeine-based medicine, after I had told her so.  So people that use these narcotics (FOR A REASON, hopefully...), know a thing or three when it comes to the actual medication.  Hope this info helped everybody.  Let's not start a war here pertaining to this information - it's stupid to argue about what medicine does what, and which medicine is stronger, and so forth.  I will not post any replies to any further information that accuses me of "misleading" everybody.  And have a great day.




Posts: 544
Joined: 2006-04-12
Tussionex is 10mg per

Tussionex is 10mg per teaspoon so if you took two tablespoons that would be 60mg of hydrocodone so of course that is going to make a migraine go away. Saying you can not get hydrocodone in more than 10mg or in extended release is a false statement no matter what you choose to believe. Also fentanyl is not a morphine derivative last I checked it is its own fully synthetic opiate. As far as the urinating problem I have noticed that with codones, morphones, and full synthetics. But you will choose to believe whatever you want I guess because your first post did have false statements in it weather you choose to believe it or not. and to answer your question about who here is a chemist....I just ended my sophomore year at college with a major in chemistry....so in two years I will be a chemist...thats at least one person here on this site. Your right it is stupid to argue about the effects of a medicine because everyone is different but saying "they dont make this" or "these two are the same" when the statements are wrong is still false. 



gcdylan's picture
Posts: 398
Joined: 2007-05-03
If there is no times release

If there is no times release for hydrocodone why is Tussionex RX's one tablespoon every 12 hrs? Just an observation I have been RX'd that some years back



gcdylan's picture
Posts: 398
Joined: 2007-05-03
I missed the post ahead of me

I missed the post ahead of me



solo5010's picture
Posts: 1128
Joined: 2005-10-06
The decision on were a drug

The decision on were a drug is placed on the drug scheduling is dependant upon:

The drug's or substance's potential for being harmful

The drug's value for medical purposes

The potential for abuse, physical dependence, or addiction

Certain stimpulations such as drug strength and whether or not a prescription can be phoned in etc., depends on its place on the CSA Drug Schedule.These arent deciding factors on where to put them on the drug schedule.

Heres a few links for ya drewfuss.

LINK

LINK 

The bottom link is to a website made by Purdue Pharma.




Posts: 8
Joined: 2008-06-06
Thx 

Thx

 




Posts: 8
Joined: 2008-06-06
and I meant two teaspoons,

and I meant two teaspoons, not tablespoons - that was a 20mg dose, the same as my oxycodone daily dosage twice per day...




Posts: 8
Joined: 2008-06-06
oh, also - when I told my

oh, also - when I told my neurologist about my urination problems, she said "ok, morphine-based meds give you problems urinating, so let's try something different for your migraines" - she was referring to the fentanyl patches.  But again, Thx




Posts: 8
Joined: 2008-06-06
and, this is for the chemist

and, this is for the chemist - what exactly is the difference, chemically, between hydrocodone, and oxycodone?  Are the structures similiar, or completely and totally different?  I'm just curious about this one, as I've been wondering about that one for a long, long time.




solo5010's picture
Posts: 1128
Joined: 2005-10-06
I know your last question

I know your last question wasnt addressed to me, but I think I can shed a little light on it for ya.  Hydrocodone is synthesised from Codeine or Thebaine, Oxycodone is usually only synthesised from Thebaine but can be made from Codeine but its a longer process. Both are structually similar to Morphine, but they arent technically "Morphine Based", they are however both made from a substance that is derived from the same plant. When it gets down to the exact differences, its going to be the placement of certain molecules in the chemicals structure that makes a difference. Depending on how the molecule is shaped will make a difference on how well it attachs to the opioid receptors in the brain, I also think it has something to do with how well it passes the blood/brain barrier (both of these factors into potency and duration of effects).

 You would think your doctor would have tried you on something like Demerol or Methadone before Fentanyl, both a pure synthetics but arent nearly as potent as Fentanyl and I think they are both significantly cheaper.




Posts: 1
Joined: 2006-04-29
it might have to do with the

it might have to do with the addiction/dependancy, oxycodone is more addictive than hydrocodone



Posts: 8
Joined: 2008-06-06
I just know personally, with

I just know personally, with my experiences I've had to go through since I've had MS, that hydrocodone just works better for me, and gives relief much quicker than oxycodone - that's just from what I've learned in my own, personal experience. 

 I've recently had my neurologist switch me from 20mg oxycodone extended-relief, to 10mg hydrocodone, because I don't drive anymore (due to this disease-thing), and it's a lot easier for me to get my dr to phone in hydrocodone, rather than having to actually go and pick up a written prescription, instead. 

I just keep having new symptoms pop up, it seems like every month.  Now I'm starting to get this pain on the bottom of my feet, as well as a pain that feels like a meat-grinder is inside of my calf bone, just digging the tissue into a pulp.  That's not even to include the daily 'morning-migraines' that I get, seems like about 5 out of every 7 mornings. 

Anyway, just thought I would share my own personal experiences with having to actually use lortab to even get through the day, without being in excruciating pain.  Peace Out -holla